- R2 RNA element
R2 RNA is a
cis-acting elementidentified in R2 retrotransposonswhich is involved in priming the reverse transcriptionprocess (an essential part of retrotransposon insertion into the host genome).
R2 is a non-long terminal repeat (non-LTR) retrotransposable element that inserts at a specific site in the 28S
ribosomal RNA(rRNA) genes of most insect genomescite journal | author = Luan DD, Korman MH, Jakubczak JL, Eickbush TH | title = Reverse transcription of R2Bm RNA is primed by a nick at the chromosomal target site: a mechanism for non-LTR retrotransposition | journal = Cell | volume = 72 | issue = 4 | pages = 595–605 | year = 1993 | pmid = 7679954 | doi = | issn = ] In order to insert itself into the genome, a retrotransposon encoded protein(R2) protein makes a specific nick in one of the DNAstrands at the insertion site and uses the 3′ hydroxyl group exposed by this nick to prime the reverse transcription process (RNA genome transcribed into DNA). This structure, an RNA element found in the R2 3'untranslated region (3'UTR), has been shown to interact with the R2 encoded reverse transcriptasein a reaction termed target primed reverse transcription (TPRT) cite journal | author = Ruschak AM, Mathews DH, Bibillo A, "et al" | title = Secondary structure models of the 3' untranslated regions of diverse R2 RNAs | journal = RNA | volume = 10 | issue = 6 | pages = 978–87 | year = 2004 | pmid = 15146081 | doi = | issn = ] .
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