CsrB/RsmB RNA family

CsrB/RsmB RNA family
Predicted secondary structure and sequence conservation of CsrB
Identifiers
Symbol	CsrB
Rfam	RF00018
Other data
RNA type	Gene; sRNA
Domain(s)	Bacteria
SO	0000377

The CsrB RNA is a non-coding RNA that binds to approximately 18 copies of the CsrA protein.^[1] Although CsrA proteins are found in a wide variety of bacteria, CsrB RNAs are only known in Enterobacter. The CsrB RNAs contain a conserved motif CAGGXXG that is found in up to 18 copies and has been suggested to bind CsrA. The Csr regulatory system has a strong negative regulatory effect on glycogen biosynthesis, glyconeogenesis and glycogen catabolism and a positive regulatory effect on glycolysis.^[2] In other bacteria such as Erwinia carotovora the RsmA protein has been shown to regulate the production of virulence determinants, such extracellular enzymes.^[3] RsmA binds to RsmB regulatory RNA which is also a member of this family.

See also

• CsrC RNA family
• PrrB/RsmZ RNA family
• RsmY RNA family
• RsmX

References

1. ^ Babitzke P, Romeo T (2007). "CsrB sRNA family: sequestration of RNA-binding regulatory proteins". Curr. Opin. Microbiol. 10 (2): 156–63. doi:10.1016/j.mib.2007.03.007. PMID 17383221. 
2. ^ Liu MY, Gui G, Wei B, et al. (1997). "The RNA molecule CsrB binds to the global regulatory protein CsrA and antagonizes its activity in Escherichia coli". J. Biol. Chem. 272 (28): 17502–10. doi:10.1074/jbc.272.28.17502. PMID 9211896. 
3. ^ Cui, Y; Chatterjee A, Liu Y, Dumenyo CK, Chatterjee AK (1995). "Identification of a global repressor gene, rsmA, of Erwinia carotovora subsp. carotovora that controls extracellular enzymes, N-(3-oxohexanoyl)-L-homoserine lactone, and pathogenicity in soft-rotting Erwinia spp". J Bacteriol 177 (17): 5108–5115. PMC 177290. PMID 7665490. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=177290. 

External links

• Rfam page for CsrB/RsmB RNA family
• Pfam page for the CsrA protein family