PrrB/RsmZ RNA family

The PrrB/RsmZ RNA family are a group of related non-coding RNA molecules found in bacteria. PrrB RNA is able to phenotypically complement gacS and gacA mutants and is itself regulated by the GacS-GacA two-component signal transduction system.cite journal | author = Aarons S, Abbas A, Adams C, Fenton A, O'Gara F | title = A regulatory RNA (PrrB RNA) modulates expression of secondary metabolite genes in "Pseudomonas fluorescens" F113 | journal = J. Bacteriol. | volume = 182 | issue = 14 | pages = 3913–9 | year = 2000 | pmid = 10869066 | doi = | issn = ] Inactivation of the prrB gene in Pseudomonas fluorescens F113 resulted in a significant reduction of 2, 4-diacetylphloroglucinol (Phl) and hydrogen cyanide (HCN) production, while increased metabolite production was observed when prrB was overexpressed. The prrB gene sequence contains a number of imperfect repeats of the consensus sequence 5'-AGGA-3', and sequence analysis predicted a complex secondary structure featuring multiple putative stem-loops with the consensus sequences predominantly positioned at the single-stranded regions at the ends of the stem-loops. This structure is similar to the CsrB and RsmB regulatory RNAs (CsrB/RsmB RNA family), suggesting this RNA also interacts with a CsrA-like protein.

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