Penitrem A

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ImageFile=Penitrem A.pngImageSize=200px
IUPACName=
OtherNames=Tremortin
Section1= Chembox Identifiers
CASNo=12627-35-9
PubChem=337313
SMILES=CC(=C)C1C(C2C3(O2)C(O1)CCC4(C3(CCC5C4(C6=C7C5OC(C8CC9C8(C1=C7C(=CC(=C1CC9=C)Cl)N6)O)(C)C)C)O)C)O
Section2= Chembox Properties
Formula=C₃₇H₄₄ClNO₆
MolarMass=634.20136
Appearance=
Density=
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BoilingPt=
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Section3= Chembox Hazards
MainHazards=
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Penitrem A (tremortin) is a fungal neurotoxin found on ryegrass. It is produced by certain species of "Aspergillus", "Claviceps", and "Penicillium". It inhibits potassium channels in smooth muscles.Fact|date=November 2007 The maxi-channels targeted have their highest density in the cerebellar Purkinje cells.

It causes a stagger in horses and cattle.

Effective dose

The ED₅₀ for penitrem A is 10 nM.Fact|date=November 2007 The ED₅₀ is the effective dose for 50% of the population. Many toxic chemicals do not show ED-50s and act by irreversible covalent adduction.

tages of toxicity

*Acute tremor
*Chronic ataxia
*Little recovery

ee also

* Neurotoxicity

References

*cite journal |author=Walter SL |title=Acute penitrem A and roquefortine poisoning in a dog |journal=Can. Vet. J. |volume=43 |issue=5 |pages=372–4 |year=2002 |pmid=12001505 |doi=