Usual interstitial pneumonia
- Usual interstitial pneumonia
Usual interstitial pneumonia, commonly abbreviated UIP, is the name of a histopathological pattern seen in diffuse lung diseases. Diffuse lung diseases are also referred to as "interstitial lung diseases".
UIP is a type of idiopathic interstitial pneumonia. Sometimes, confusingly, it is used as a synoym for idiopathic pulmonary fibrosis.
Differential diagnosis
UIP is seen in:[cite book |author=Wick, Mark R.; Leslie, Kevin |title=Practical pulmonary pathology: a diagnostic approach |publisher=Churchill Livingstone |location=Edinburgh |year=2005 |pages= |isbn=0-443-06631-0 |oclc= 156861539|doi= |accessdate=] ]
*idiopathic pulmonary fibrosis,
*asbestosis,
*chronic hypersensitivity pneumonitis,
*collagen vascular disease and
*chronic drug toxicity. [cite journal |author=Rossi SE, Erasmus JJ, McAdams HP, Sporn TA, Goodman PC |title=Pulmonary drug toxicity: radiologic and pathologic manifestations |journal=Radiographics : a review publication of the Radiological Society of North America, Inc |volume=20 |issue=5 |pages=1245–59 |year=2000 |pmid=10992015 |doi=] Histologic appearance
UIP is characterized by:
*interstitial inflammation,
*fibroblast foci,
*(microscopic) honeycombing and
*patchy lesional distribution (heterogeneous areas of abnormal and normal lung).
History and application of term
UIP, as a term, first appeared in the pathology literature. It was coined by Averill Abraham Liebow. [WhoNamedIt|doctor|2548|Averill Abraham Liebow]
It is sometimes, confusingly, used to refer to idiopathic pulmonary fibrosis, one of its many clinical correlates.
Pneumonia misnomer?
The definition of "pneumonia" is often described as a '... lung inflammation caused by a virus, bacteria or irritant.' [cite web |url=http://dictionary.reference.com/browse/pneumonia |title=Pneumonia definition |publisher=Dictionary.com |format= |work= |accessdate=]
Etymologically, the usage of "pneumonia" in UIP is correct; the word "pneumonia" is derived from "pneumon" (lung) and the suffix "-ia" (condition). [EMedicineDictionary|pneumonia]
ee also
*Pneumoconiosis
*Silicosis
*Asbestosis
References
Wikimedia Foundation.
2010.
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