Insulin receptor substrate
- Insulin receptor substrate
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Insulin receptor substrate (IRS) is an important ligand in the insulin response of human cells.
IRS-1, for example, is an IRS protein which contains a phosphotyrosine binding-domain (PTB-domain). In addition, the insulin receptor contains a NPXpY domain. The PTB-domain binds the NPXpY domain. Thus, the insulin receptor binds IRS.
Genes
References
- van der Geer P, Wiley S, Pawson T (1999). "Re-engineering the target specificity of the insulin receptor by modification of a PTB domain binding site". Oncogene 18 (20): 3071–5. doi:10.1038/sj.onc.1202879. PMID 10340378.
Categories:
- Coordination chemistry
- Chemical bonding
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