- Fenretinide
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ImageFile = Fenretinide.svg
ImageSize = 250px
IUPACName = (2"E",4"E",6"E",8"E")-"N"-(4-hydroxyphenyl)-3,7-
dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)
nona-2,4,6,8-tetraenamide
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Section1 = Chembox Identifiers
CASNo = 65646-68-6
PubChem = 5288209
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MeSHName = Fenretinide
Section2 = Chembox Properties
Formula = C26H33NO2
MolarMass = 391.546 g/mol
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Autoignition =Fenretinide (4-hydroxy(phenyl)retinamide) (INN) is a synthetic
retinoid deriverative which are substances related to vitamin A. It has been investigated for potential use in the treatment ofcancer , as well as in the treatment of cystic fibrosis, rheumatoid arthritis, acne, psoriasis, and has been found to also slow the production and accumulation of a toxin that leads to vision loss in Stargardt's patients.In cancer studies, Fenretinide treatment may cause ceramide (a wax-like substance) to build up in tumor cells and is associated with the accumulation of reactive oxygen species (ROS), resulting in cell death through apoptosis and/or necrosis. Fenretinide is thought to accumulate preferentially in fatty tissue such as the breast, which may contribute to the effectiveness of fenretinide against breast cancer; phase III clinical trial data has suggested that fenretinide reduces breast cancer relapse in pre-menopausal women. Common side effects associated with fenretinide treatment include skin dryness and night-blindness, which is reversible upon cessation of treatment. Specific types of cancer under investigation include bladder, breast, Non-Hodgkin's lymphoma, neuroblastoma, and Ewing's sarcoma.
Numerous references and links to current and past clinical trials and studies of Fenretinide can be found at the Journal of Clinical Oncology website athttp://jco.ascopubs.org/cgi/content/abstract/19/6/1664
[cite journal |author=Wu J, DiPietrantonio A, Hsieh T |title=Mechanism of fenretinide (4-HPR)-induced cell death |journal=Apoptosis |volume=6 |issue=5 |pages=377–88 |year=2001 |pmid=11483862 |doi=10.1023/A:1011342220621]
References
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