Glomerular basement membrane
- Glomerular basement membrane
Infobox Anatomy
Name = PAGENAME
Latin =
GraySubject =
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Caption = Glomerulus. (Diagram in French, but "Membrane basale glomerulaire et ses podocytes" labeled near center.)
Caption2 =
Precursor =
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Artery =
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Lymph =
MeshName = glomerular+basement+membrane
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DorlandsPre = m_08
DorlandsSuf = 12522684
The glomerular basement membrane is the basal laminal portion of the glomerulus which performs the actual filtration though the filtration slits between the podocytes, separating the blood on the inside from the filtrate on the outside. It is a fusion of the endothelial cell and podocyte basal laminas. [GeorgiaPhysiology|7/7ch04/7ch04p07 - "Basement Membrane"]
Layers
The GBM contains three layers: [ [http://www.jci.org/cgi/content/full/116/8/2090/F1 JCI - New articles published ] ]
Pathology
* Goodpasture's syndrome is also known as "anti-glomerular basement membrane disease". Capillaries become inflamed as a result of damage to the basement membrane by antibodies.
* Nephrotic syndrome is a change in the structure of the glomerular filtration mechanism usually in the glomerular basement membrane. Some symptoms include proteinuria, hypoalbuminaemia, oedema, and hyperlipidemia.
* Diabetic glomerulosclerosis is a thickening of the basement membrane, which can become up to 4-5 times thicker than normal. Can be caused by insulin deficiency or resultant hyperglycemia.
ee also
* basement membrane
* nephrin
References
External links
*
* [http://renux.dmed.ed.ac.uk/EdREN/EdRenINFObits/GBMdisorders.html#anchor10086420 "The GBM and its disorders" at dmed.ed.ac.uk]
* [http://membranebiology.mgh.harvard.edu/KidneyImages/Kidneyanatomy/HumanCortexStains.html Histology at harvard.edu]
* [http://www.wramc.army.mil/departments/Medicine/Nephrology/education/Lectures/chronic_gn/sld011.htm Structure at wramc.army.mi]
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