- Janeway lesion
Janeway lesions are non-
tender , smallerythematous orhaemorrhagic macular or nodular lesions on thepalms or soles only a few millimeters in diameter that arepathognomonic of infective endocarditis.cite journal | last = Farrior | first = J.B. | coauthors = Silverman M.E. | title = A consideration of the differences between a Janeway's lesion and an Osler's node in infectious endocarditis |journal = Chest. | volume = 70 | issue = 2 | pages = 239–43 | year = 1976 | pmid = 947688 | doi = 10.1378/chest.70.2.239] Pathologically, the lesion is described to be a microabscess of thedermis with markednecrosis and inflammatory infiltrate not involving the epidermis, which is due to the deposition of circulatingimmune complexes in small blood vessels.They are named after
Edward G. Janeway (1841–1911), aprofessor ofmedicine with interests incardiology andinfectious disease . [cite journal |author=Janeway C. |title=Presidential Address to The American Association of Immunologists. The road less traveled by: the role of innate immunity in the adaptive immune response |journal=J. Immunol. |volume=161 |issue=2 |pages=539–44 |year=1998 |pmid=9670925]ee also
*
Osler's node s
*Roth's spot sReferences
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