Thorpe reaction

Thorpe reaction

The Thorpe reaction is a chemical reaction described as a self-condensation of aliphatic nitriles catalyzed by base to form enamines.Ref|Baron1904Ref|Ziegler1933Ref|Schaefer1967 The reaction was discovered by Jocelyn Field Thorpe.

Thorpe-Ziegler reaction

The Thorpe-Ziegler reaction or Ziegler method is the intramolecular modification with a dinitrile as a reactant and a cyclic ketone as the final reaction product after acidic hydrolysis. The reaction is conceptually related to the Dieckmann condensation and named after Karl Ziegler.

External links

* Thorpe-Ziegler reaction: "4-Phosphorinanone, 1-phenyl-" Organic Syntheses, Coll. Vol. 6, p.932 (1988); Vol. 53, p.98 (1973) [http://www.orgsynth.org/orgsyn/pdfs/CV6P0932.pdf Link]

References

# Baron, H.; Remfry, F. G. P.; Thorpe, Y. F. "J. Chem. Soc." 1904, "85", 1726.
# Karl Ziegler "et al." "Ann." 1933, "504", 94.
# Schaefer, J. P.; Bloomfield, J. J. "Org. React." 1967, "15", 1. (Review)


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