Q fever

MeshID = D011778

Q fever is a disease caused by infection with "Coxiella burnetii", a bacterium that affects both humans and animals. This organism is uncommon but may be found in cattle, sheep, goats and other domestic mammals, including cats and dogs. The infection results from inhalation of contaminated particles in the air, and from contact with the vaginal mucus, milk, feces, urine or semen of infected animals. The incubation period is 9-40 days. It is considered possibly the most infectious disease in the world, as a human being can be infected by a single bacterium. [ [http://www.cdc.gov/ncidod/dvrd/qfever/ Q fever caused by Coxiella burnetii ] ]

History

It was first described by Edward Holbrook Derrick in abattoir workers in Brisbane, Queensland, Australia. The "Q" stands for “query” and was applied historically at a time when the causative agent was unknown.

The pathogen of Q fever was discovered in 1937, when Frank Macfarlane Burnet and Mavis Freeman isolated the bacterium from one of Derrick’s patients.Fact|date=December 2007 It was originally identified as a species of "Rickettsia". H.R. Cox and Davis isolated it from ticks in Montana, USA in 1938, and called it "Rickettsia diasporica".Fact|date=December 2007 "R. diasporica" was considered non-pathogenic until laboratory investigators were infected;Fact|date=December 2007 it was officially renamed "Coxiella burnetii" the same year. It is a zoonotic disease whose most common animal reservoirs are cattle, sheep and goats. "Coxiella burnetii" is no longer regarded as closely related to Rickettsiae.

Manifestations

Incubation period is usually 2 to 3 weeks.The most common manifestation is flu-like symptoms with abrupt onset of fever, malaise, profuse perspiration, severe headache, myalgia (muscle pain), joint pain, loss of appetite, upper respiratory problems, dry cough, pleuritic pain, chills, confusion and gastro-intestinal symptoms such as nausea, vomiting and diarrhea. The fever lasts approximately 7 to 14 days.

During the course, the disease can progress to an atypical pneumonia, which can result in a life threatening acute respiratory distress syndrome (ARDS), whereby such symptoms usually occur during the first 4 to 5 days of infection.

Less often the Q fever causes (granulomatous) hepatitis which becomes symptomatic with malaise, fever, liver enlargement (hepatomegaly), pain in the right upper quadrant of the abdomen and jaundice (icterus). Retinal vasculitis is a rare manifestation of Q fever. [cite journal|author=Kuhne F, Morlat P, Riss I, "et al."|title=Is A29, B12 vasculitis caused by the Q fever agent? ("Coxiella burnetii")|journal=J Fr Ophtalmol|year=1992|volume=15|pages=315–21|pmid=1430809|language=French]

The chronic form of Q fever is virtually identical to inflammation of the inner lining of the heart (endocarditis), which can occur months or decades following the infection. It is usually deadly if untreated. However, with appropriate treatment the mortality falls to around 10%.

Appearance and incidence

The pathogenic agent is to be found everywhere except Antarctica and New Zealand. In Europe it appears as hepatitis rather than pneumonia as in the United States. The bacterium is extremely sustainable and infectious: a single organism is able to cause an infection. The common way of infection is inhalation of contaminated dust, contact with contaminated milk, meat, wool and particularly birthing products. Ticks can transfer the pathogenic agent to other animals. Transfer between humans seems extremely rare and has so far been described in very few cases.

Men are slightly more often affected than women, which most likely is attributed to different employment rates in typical professions.

"At risk" occupations include, but are not limited to:
* veterinary personnel
* stockyard workers
* farmers
* shearers
* animal transporters
* laboratory workers handling potentially infected veterinary samples or visiting abattoirs
* people who cull and process kangaroos
* hide (tannery) workers.

Diagnosis

Diagnosis is usually based on serology (looking for an antibody response) rather than looking for the organism itself. Serology allows to detect chronic infection as high antibody levels are found against the virulent form of the bacterium. Molecular detection of bacterial DNA is increasingly used. Culture is technically difficult and not routinely available in most microbiology laboratories.

Q fever can cause endocarditis (infection of the heart valves) which may require transoesophageal echocardiography to diagnose. Q fever hepatitis manifests as an elevation of ALT and AST, but a definitive diagnosis is only possible on liver biopsy which shows the characteristic fibrin ring granulomas. [cite journal | title=Patient with fever and diarrea | author=van de Veerdonk FL, Schneeberger PM. | journal=Clin Infect Dis | year=2006 | volume=42 | pages=1051–2 | doi=10.1086/501027 ]

Treatment

Treatment of the acute Q fever with antibiotics is very effective and should take place in consultation with an infectious diseases specialist. Commonly used are doxycycline, tetracycline, chloramphenicol, ciprofloxacin, ofloxacin, and hydroxychloroquine. The chronic form is more difficult to treat and can require up to four years of treatment with doxycycline and quinolones or doxycycline with hydroxychloroquine.

Q fever in pregnancy is especially difficult to treat because doxycycline and ciprofloxacin are contraindicated in pregnancy. The preferred treatment is five weeks of co-trimoxazole. [cite journal|journal=Clin Infect Dis|year=2007|volume=45|pages=548–555|title=Managing Q fever during pregnancy: The benefits of long-term Cctrimoxazole therapy|author=Carcopino X, Raoult D, Bretelle F, Boubli L, Stein A|url=http://www.journals.uchicago.edu/CID/journal/issues/v45n5/51070/51070.html | doi = 10.1086/520661 |format=dead link|date=June 2008 – ^{[http://scholar.google.co.uk/scholar?hl=en&lr=&q=intitle%3AManaging+Q+fever+during+pregnancy%3A+The+benefits+of+long-term+Cctrimoxazole+therapy&as_publication=Clin+Infect+Dis&as_ylo=2007&as_yhi=2007&btnG=Search Scholar search]} ]

Prevention

Q fever is effectively prevented by intradermal vaccination with a vaccine composed of killed "Coxiella burnetii" organisms. Skin and blood tests should be done before vaccination to identify preexisting immunity; the reason is that vaccinating subjects who already have an immunity can result in a severe local reaction. After a single dose of vaccine, protective immunity lasts for many years. Revaccination is not generally required. Annual screening is typically recommended. [http://cdp.ucsf.edu/fileUpload/UCSF_CDP_Q_Fever_Surveillance_Policy_Q_Neg_Wethers.pdf]

In 2001, Australia introduced a national Q fever vaccination program for people working in "at risk" occupations.

Biological warfare

The United States investigated Q fever as a potential biological warfare agent in the 1950s with eventual standardization as agent OU. At Fort Detrick and Dugway Proving Ground human trials were conducted on Whitecoat volunteers to determine the median infective dose (18 MICLD₅₀/person i.h.) and course of infection. As a standardized biological it was manufactured in large quantities at Pine Bluff Arsenal, with 5,098 gallons in the arsenal in bulk at the time of demilitarization in 1970.

Q fever is a category "B" agent. It can be contagious and is very stable in aerosols in a wide range of temperatures. Q fever microorganisms may survive on surfaces up to 60 days.

The Soviet Union had a killed vaccine against it to protect animal handlers that had side effects precluding its licensing abroad. Protection against the disease today is offered by Q-Vax, a whole cell inactivated vaccine developed by a leading Australian vaccine manufacturing company CSL.(http://www.csl.com.au/QFever.asp)

References

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* http://www.csl.com.au/QFever.asp