- Vibrio cholerae
color = lightgrey
name = "Vibrio cholerae"
image_width = 250px
image_caption = TEM image
regnum = Bacteria
classis = Gamma Proteobacteria
ordo = Vibrionales
genus = "
species = "V. cholerae"
binomial = "Vibrio cholerae"
binomial_authority = Pacini 1854
"Vibrio cholerae" (also "Kommabacillus") is a
gram negativecurved-rod shaped bacteriumwith a polar flagellathat causes cholerain humans.cite book | author = Ryan KJ; Ray CG (editors) | title = Sherris Medical Microbiology | edition = 4th ed. | publisher = McGraw Hill | year = 2004 | id = ISBN 0838585299 ] cite book | author = Faruque SM; Nair GB (editors). | title = Vibrio cholerae: Genomics and Molecular Biology | publisher = Caister Academic Press | year = 2008 | url=http://www.horizonpress.com/vib | id = [http://www.horizonpress.com/vib ISBN 978-1-904455-33-2 ] ] "V. cholerae" and other species of the genus" Vibrio" belong to the gamma subdivision of the Proteobacteria. There are two major strains of "V. cholerae", classic and El Tor, and numerous other serogroups.
"V. cholerae" was first isolated as the cause of cholera by Italian anatomist
Filippo Paciniin 1854, but his discovery was not widely known until Robert Koch, working independently thirty years later, publicized the knowledge and the means of fighting the disease.Fact|date=February 2007
"V. cholerae" occurs naturally in the
planktonof fresh, brackish, and salt water, attached primarily to copepods in the zooplankton. Coastal cholera outbreaks typically follow zooplankton blooms. This makes cholera a typical zoonosis.
"V. cholerae" colonizes the
gastrointestinaltract, where it adheres to villi.Additionally, it produces two different proteases called chitinase and mucinase. Chitinaseis responsible for the ability of "Vibrio cholerae" to enter copapods. Mucinase is a non-specific protease that assists entry into the human gastro-intestinal tract.
"Vibrio cholerae" produces what is called a ZOT, termed as "Zona Occludans Toxin". This toxin specifically attacks the zona occludans or "tight" junctions joining epithelial cells.
Genomics and Evolution
The 4.0 Mbp
genomeof N16961, an O1 serogroup, El Tor biotype, 7th pandemic strain of "V. cholerae", is comprised of two circular chromosomes of unequal size that are predicted to encode a total of 3,885 genes. The genomic sequence of this representative strain has furthered our understanding of the genetic and phenotypic diversity found within the species "V. cholerae". Sequence data have been used to identify horizontally acquired sequences, dissect complex regulatory and signaling pathways, and develop computational approaches to predict patterns of gene expressionand the presence of metabolic pathwaycomponents. Microarrays are being used to study the evolution of the organism. Genomic sequencing of additional strains, subtractive hybridizationstudies and the introduction of new model systems have also contributed to the identification of novel sequences and pathogenic mechanisms associated with other strains.cite book | author = Faruque SM; Nair GB (editors). | title = Vibrio cholerae: Genomics and Molecular Biology | publisher = Caister Academic Press | year = 2008 | url=http://www.horizonpress.com/vib | id = [http://www.horizonpress.com/vib ISBN 978-1-904455-33-2 ] ]
* [http://www.nsf.gov/news/speeches/colwell/rc01_anatlesson/tsld024.htm Copepods and cholera in untreated water]
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