3Beta Hydroxysteroid dehydrogenase
- 3Beta Hydroxysteroid dehydrogenase
3 β-Hydroxysteroid dehydrogenase, or 3 β-HSD is a group of steroidogenic enzymes. [cite journal
author = Payne AH, Abbaszade IG, Clarke TR, Bain PA, Park CH
title = The multiple murine 3 beta-hydroxysteroid dehydrogenase isoforms: structure, function, and tissue- and developmentally specific expression.
journal = Steroids
volume = 62
issue = 1
pages = 169–75
publisher = Elsevier
date = January 1997
pmid = 9029733
accessdate = 2006-08-16
doi = 10.1016/S0039-128X(96)00177-8]
The main steroidogenic isoform, 3 β-HSD I, catalyzes the conversion of pregnenolone to progesterone, the conversion of 17-Hydroxypregnenolone to 17-Hydroxyprogesterone, and the conversion of DHEA to Androstenedione.
It is mainly expressed in the gonads and the adrenal cortex.
Pathway
References
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