Name = Acidosis
DiseasesDB = 87
ICD10 = ICD10|E|87|2|e|70
ICD9 = ICD9|276.2 | ICDO =
MeshID = D000138
Acidosis is an increased
acidity(i.e. an increased hydrogen ion concentration). If not further qualified, it refers to acidity of the blood plasma.
Acidosis is said to occur when arterial
pHfalls below 7.35, while its counterpart ( alkalosis) occurs at a pH over 7.45. Arterial blood gasanalysis and other tests are required to separate the main causes.
The term "acidemia" describes the state of low blood pH, while "acidosis" is used to describe the processes leading to these states. Nevertheless, physicians sometimes use the terms interchangeably. The distinction may be relevant where a patient has factors causing both acidosis and alkalosis, where the relative severity of both determines whether the result is a high or a low pH.
The rate of cellular metabolic activity affects and, at the same time, is affected by the pH of the body fluids. In mammals, the normal pH of arterial blood lies between 7.35 and 7.50 depending on the species (e.g. healthy human-arterial blood pH varies between 7.35 and 7.45). Blood pH values compatible with life in mammals are limited to a pH range between 6.8 and 7.8. Changes in the pH of arterial blood (and therefore the extracellular fluid) outside this range result in irreversible cell damage (Needham, 2004).
Respiratory acidosisresults from a build-up of carbon dioxide in the blood (hypercapnia) due to hypoventilation. It is most often caused by pulmonary problems, although head injuries, drugs (especially anaesthetics and sedatives), and brain tumors can also bring it on. Pneumothorax, emphysema, chronic bronchitis, asthma, severe pneumonia, and aspiration are among the most frequent causes. It can also occur as a compensatory response to chronic metabolic alkalosis.
One key to distinguish between respiratory and metabolic acidosis is that in respiratory acidosis, the CO2 is increased while the
bicarbonateis either normal (uncompensated) or increased (compensated). Compensation occurs if respiratory acidosis is present, and a chronic phase is entered with partial buffering of the acidosis through renal bicarbonate retention.
However, in cases where chronic illnesses which compromise pulmonary function persist, such as late-stage emphysema and certain types of
muscular dystrophy, compensatory mechanisms will be unable to reverse this acidotic condition. As metabolic bicarbonate production becomes exhausted, and extraeneous bicarbonate infusion can no longer reverse the extreme buildup of carbon dioxide associated with uncompensated respiratory acidosis, mechanical ventilationwill usually be applied. [http://www.nlm.nih.gov/medlineplus/ency/article/000092.htm] [http://www.emedicine.com/MED/topic2008.htm]
Metabolic acidosisis an increased production of metabolic acids, usually resulting from disturbances in the ability to excrete acid via the kidneys. Renal acidosis is associated with an accumulation of urea and creatinine as well as metabolic acid residues of protein catabolism.
An increase in the production of other acids may also produce metabolic acidosis. For example, lactic acidosis may occur from 1 severe (PaO2 <36mm Hg) hypoxemia causing a fall in the rate of oxygen diffusion from arterial blood to tissues, or 2
hypoperfusion(e.g. hypovolemic shock) causing an inadequate blood delivery of oxygen to tissues. A rise in lactate out of proportion to the level of pyruvate, e.g. in mixed venous blood, is termed "excess lactate", and may also be an indicator of fermention due to anaerobic metabolism occurring in muscle cells, as seen during strenuous exercise. Once oxygenation is restored, the acidosis clears quickly. Another example of increased production of acids occurs in starvation and diabetic acidosis. It is due to the accumulation of ketoacids (ketosis) and reflects a severe shift from glycolysis to lipolysisfor energy needs.
Acid consumption from
poisoning, elevated levels of ironin the blood, and chronically decreased production of bicarbonatemay also produce metabolic acidosis.
Metabolic acidosis is compensated for in the lungs, as increased exhalation of carbon dioxide promptly shifts the buffering equation to reduce metabolic acid. This is a result of stimulation to chemoreceptors which increases
alveolar ventilation, leading to respiratory compensation, otherwise known as Kussmaul breathing(a specific type of hyperventilation). Should this situation persist the patient is at risk for exhaustion leading to respiratory failure.
Mutations to the
V-ATPase'a4' or 'B1' isoforms result in distal renal tubular acidosis, a condition that leads to metabolic acidosis, in some cases with sensorineural deafness. Arterial blood gasses will indicate low pH, low blood HCO3, and normal or low PaCO2. In addition to arterial blood gas, an anion gapcan also differentiate between possible causes.
Henderson-Hasselbalch equationis useful for calculating blood pH, because blood is a buffer solution. The amount of metabolic acid accumulating can also be quantitated by using buffer base deviation, a derivative estimate of the metabolic as opposed to the respiratory component. In hypovolemic shock for example, approximately 50% of the metabolic acid accumulation is lactic acid, which disappears as blood flow and oxygen debt are corrected.
Treatment of uncompensated metabolic acidosis is focused upon correcting the underlying problem. When metabolic acidosis is severe and can no longer be compensated for adequately by the lungs, neutralizing the acidosis with infusions of
bicarbonatemay be required.
Mixed disorder of acid-base balance
*Hobler KE, Carey LC. Effect of acute progressive hypoxemia on cardiac output and plasma excess lactate. Ann Surg. 1973 Feb;177(2):199-202.
*Hobler KE, Napodano RJ, Tolerance of swine to acute blood volume deficits.
*J Trauma. 1974 Aug;14(8):716-8.
* [http://books.mcgraw-hill.com/getbook.php?isbn=0071346821&template=medical Clinical Physiology of Acid-Base and Electrolyte Disorders by Rose, Post]
* [http://www.lww.com/product/?0-7817-3548-3 Intensive Care Medicine by Irwin and Rippe]
* [http://www.lww.com/product/?0-683-05565-8 The ICU Book by Marino]
*Needham, A. 2004. Comparative and Environmental Physiology Acidosis and Alkalosis.
* [http://kidney.niddk.nih.gov National Kidney and Urologic Diseases Information Clearinghouse]
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