Frontal lobe

Infobox Brain
Name = Frontal lobe
Latin = lobus frontalis
GraySubject = 189
GrayPage = 821


MapPos =
MapCaption = Principal fissures and lobes of the cerebrum viewed laterally. (Frontal lobe is blue.)


Caption =


Caption2 = Orbital surface of left frontal lobe.
IsPartOf = Cerebrum
Components =
Artery = Anterior cerebral Middle cerebral
Vein =
Acronym = FL
BrainInfoType = hier
BrainInfoNumber = 37
MeshName = Frontal+Lobe
MeshNumber = A08.186.211.730.885.213.270
The frontal lobe is an area in the brain of mammals. It is located at the front of each cerebral hemisphere and positioned anterior to (in front of) the parietal lobes and above and anterior to the temporal lobes. It is separated from the parietal lobe by the primary motor cortex, which controls voluntary movements of specific body parts associated with the precentral gyrus.

The frontal lobe reaches full maturity around age 25, marking the cognitive maturity associated with adulthood. Arthur Toga, UCLA, found increased myelin in the frontal lobe white matter of young adults compared to that of teens. Typical onset of schizophrenia in early adult years correlates with poorly myelinated and thus inefficient connections between cells in the fore-brain.

The frontal lobe contains most of the dopamine-sensitive neurons in the cerebral cortex. The dopamine system is associated with pleasure, long-term memory, planning, and drive. Dopamine tends to limit and select sensory information arriving from the thalamus to the fore-brain. A report from the National Institute of Mental Health says a gene variant that reduces dopamine activity in the prefrontal cortex is related to poorer performance and inefficient functioning of that brain region during working memory tasks, and to slightly increased risk for schizophrenia.

Function

The executive functions of the frontal lobes involve the ability to recognize future consequences resulting from current actions, to choose between good and bad actions (or better and best), override and suppress unacceptable social responses, and determine similarities and differences between things or events.

The frontal lobes also play an important part in retaining longer term memories which are not task-based. These are often memories associated with emotions derived from input from the brain's limbic system. The frontal lobe modifies those emotions to generally fit socially acceptable norms.

Psychological tests that measure frontal lobe function include Finger tapping, Wisconsin Card Sorting Task, and measures of verbal and figural fluency. [Kimberg, D.Y., Farah, M.J. A unified account of cognitive impariments following frontal lobe da
]

Psychosurgery

In the early 20th century, a medical treatment for mental illness, first developed by Portuguese neurologist Egas Moniz, involved damaging the pathways connecting the frontal lobe to the limbic system. Frontal lobotomy (sometimes called frontal leucotomy) successfully reduced distress but at the cost of often blunting the subject's emotions, volition and personality. The indiscriminate use of this psychosurgical procedure, combined with its severe side effects and dangerous nature, gained it a bad reputation. The frontal lobotomy has largely died out as a psychiatric treatment.

More precise psychosurgical procedures are still used, although rarely. They may include anterior capsulotomy (bilateral thermal lesions of the anterior limbs of the internal capsule) or the bilateral cingulotomy (involving lesions of the anterior cingulate gyri) and might be used to treat otherwise untreatable obsessional disorders or clinical depression.

Theories of function

Theories of frontal lobe function can be differentiated into four categories:
* Single-process theories. Posit "that damage to a single process or system is responsible for a number of different dysexecutive symptoms” (Burgess, 2003, p. 309).
* Multi-process theories. Propose “that the frontal lobe executive system consists of a number of components that typically work together in everyday actions [(heterogeneity of function)] “ (Burgess, 2003, p. 310).
* Construct-led theories. Assume “that most if not all frontal functions can be explained by one construct (homogeneity of function) such as working memory or inhibition” (Stuss, 1999, p. 348; cf. Burgess & Simons, 2005).
* Single-symptom theories. Suggest that a specific dysexecutive symptom (e.g., confabulation) is related to the processes and construct of the underlying structures (cf. Burgess & Simons, 2005)

Stuss (1999) suggests a differentiation into two categories according to homogeneity and heterogeneity of function.

Further theoretical approaches to frontal lobe function include:
* Grafman's managerial knowledge units (MKU) / structured event complex (SEC) approach (cf. Wood & Grafman, 2003)
* Miller & Cohen's integrative theory of prefrontal functioning (e.g. Miller & Cohen, 2001)
* Rolls's stimulus-reward approach and Stuss's anterior attentional functions (Burgess & Simons, 2005; Burgess, 2003; Burke, 2007).

It may be highlighted that the theories described above differ in their focus on certain processes/systems or construct-lets. Stuss (1999) remarks that the question of homogeneity (single construct) or heterogeneity (multiple processes/systems) of function “may represent a problem of semantics and/or incomplete functional analysis rather than an unresolvable dichotomy” (p. 348). However, further research will show if a unified theory of frontal lobe function that fully accounts for the diversity of functions will be available.

Damage

Damage to the frontal lobes can lead to a variety of results:
*Mental flexibility and spontaneity are impaired, but IQ is not reduced.
*Talking may increase or decrease dramatically.
*Perceptions regarding risk taking and rule abiding are impaired.
*Socialization can diminish or increase.
*Orbital frontal lobe damage can result in peculiar sexual habits.
*Dorsolateral frontal lobe damage reduces sexual interest.

=Additional

=See=

*Brain lobes
*Broca's Area
*Regions in the human brain
*Phineas Gage - Railroad worker who survived a metal rod being driven through his forebrain

References