- Thioacetazone
Drugbox
IUPAC_name = N- [4- [(carbamothioylhydrazinylidene) methyl] phenyl] acetamide
CAS_number=104-06-3
ATC_prefix=J04
ATC_suffix=AM04
ATC_supplemental=
PubChem=
DrugBank=
C=10 | H=12 | N=4 | O=1 | S=1
molecular_weight = 236.3
bioavailability=
metabolism =
elimination_half-life=
excretion =
pregnancy_category =
legal_status =
routes_of_administration= OralThioacetazone(INN and BAN) is also called thiocetazone, thiacetazone, thiosemicarbazone, benzothiozane or amithiozone(USAN); abbreviated T.
Thioacetazone is used in the treatment of
tuberculosis ; it has only weak activity against "Mycobacterium tuberculosis " and is only useful in preventing resistance to more powerful drugs likeisoniazid andrifampicin . It is never used on its own to treattuberculosis ; it is used in a similar way toethambutol . Thioacetazone is the only anti-TB drug that is ineffective when given intermittently.There is no advantage to using thioacetazone if the regimen used already contains ethambutol, but many countries in sub-Saharan Africa still use thioacetazone because it is extremely cheap. Use of thioacetazone is declining because it can cause severe (sometimes fatal) skin reactions in HIV positive patients.cite journal
author=Rieder HL, Arnadottir T, Trebucq A, Enarson DA
title=Tuberculosis treatment: dangerous regimens?
journal=Int J Tuberc Lung Dis
year=2001
volume=5
issue=1
pages=1–3
pmid=11263509 ] cite journal
author=Nunn P, Porter J, Winstanley P
title=Thiacetazone—avoid like poison or use with care?
journal=Trans R Soc Trop Med Hyg
year=1993
volume=87
issue=5
pages=578–82
pmid=7505496
doi=10.1016/0035-9203(93)90096-9 ]References
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