- Orotate phosphoribosyltransferase
-
Orotate phosphoribosyltransferase 
S. cerevisiae orotate phosphoribosyl transferase bound to its substrates. From PDB file 2PSI.[1] Identifiers EC number 2.4.2.10 CAS number 9030-25-5 Databases IntEnz IntEnz view BRENDA BRENDA entry ExPASy NiceZyme view KEGG KEGG entry MetaCyc metabolic pathway PRIAM profile PDB structures RCSB PDB PDBe PDBsum Gene Ontology AmiGO / EGO Search PMC articles PubMed articles Orotate phosphoribosyltransferase is an enzyme involved in pyrimidine biosynthesis. It catalyzes the formation of orotidine 5'-monophosphate (OMP) from orotate and phosphoribosyl pyrophosphate.[1] In yeast and bacteria, orotate phospohribosyltransferase is an independent enzyme with a unique gene coding for the protein, whereas in mammals and other multicellular organisms, the catalytic function is carried out by a domain of the bifunctional enzyme UMP synthase.[2]
References
- ^ a b González-Segura L, Witte JF, McClard RW, Hurley TD (December 2007). "Ternary complex formation and induced asymmetry in orotate phosphoribosyltransferase". Biochemistry 46 (49): 14075–86. doi:10.1021/bi701023z. PMID 18020427.
- ^ Yablonski MJ, Pasek DA, Han BD, Jones ME, Traut TW. (1996). "Intrinsic activity and stability of bifunctional human UMP synthase and its two separate catalytic domains, orotate phosphoribosyltransferase and orotidine-5'-phosphate decarboxylase.". J Biol Chem. 271 (18): 10704–10708. doi:10.1074/jbc.271.18.10704. PMID 8631878.
Categories:- EC 2.4.2
Wikimedia Foundation. 2010.
