OTUD6B

OTU domain containing 6B
Identifiers
Symbols	OTUD6B;
External IDs	OMIM: 612021 HomoloGene: 6064 GeneCards: OTUD6B Gene
Gene Ontology Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51633	72201
Ensembl	ENSG00000155100	ENSMUSG00000040550
UniProt	Q8N6M0	Q8K2H2
RefSeq (mRNA)	NM_016023	NM_152812.3
RefSeq (protein)	NP_057107	NP_690025.2
Location (UCSC)	Chr 8: 92.08 – 92.1 Mb	Chr 4: 14.74 – 14.75 Mb
PubMed search	[1]	[2]

OTU domain containing 6B is a protein that in humans is encoded by the OTUD6B gene.^[1]

OTUD6B is a functional deubiquitinating enzyme, a class of protease that specifically cleaves ubiquitin linkages, negating the action of ubiquitin ligases. OTUD6B, also known as DUBA5, belongs to a DUB subfamily characterized by an ovarian tumor domain (OTU).^[1]

References

1. ^ ^{a b} "Entrez Gene: OTU domain containing 6B". http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=retrieve&list_uids=51633. Retrieved 2011-08-30. 

Further reading

• Xu Z, Zheng Y, Zhu Y, et al. (2011). "Evidence for OTUD-6B participation in B lymphocytes cell cycle after cytokine stimulation.". PLoS ONE 6 (1): e14514. doi:10.1371/journal.pone.0014514. PMID 21267069. 
• Lai CH, Chou CY, Chang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310876. 
• Sowa ME, Bennett EJ, Gygi SP, Harper JW (2009). "Defining the human deubiquitinating enzyme interaction landscape.". Cell 138 (2): 389–403. doi:10.1016/j.cell.2009.04.042. PMC 2716422. PMID 19615732. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2716422.