OSMotic avoidance abnormal family member (osm-9) (Caenorhabditis elegans)
Symbol OSM-9
Entrez 177117
Other data

OSM-9 also known as OSMotic avoidance abnormal family member 9 is a protein which in the nematode worm C. elegans is encoded by the osm-9 gene.[1]


The OSM-9 protein is required for some olfactory and osmotic stimuli as well as a mechanosensory response to nose touch. This protein encodes a protein with ankyrin repeats and is closely related in sequence to the mammalian TRPV ion channels.[1] OSM-9 controls the biosynthesis of serotonin via regulation of the expression of the enzyme tryptophan hydroxylase.[2]


  1. ^ a b Colbert HA, Smith TL, Bargmann CI (November 1997). "OSM-9, a novel protein with structural similarity to channels, is required for olfaction, mechanosensation, and olfactory adaptation in Caenorhabditis elegans". J. Neurosci. 17 (21): 8259–69. PMID 9334401. http://www.jneurosci.org/cgi/pmidlookup?view=long&pmid=9334401. 
  2. ^ Zhang S, Sokolchik I, Blanco G, Sze JY (April 2004). "Caenorhabditis elegans TRPV ion channel regulates 5HT biosynthesis in chemosensory neurons". Development 131 (7): 1629–38. doi:10.1242/dev.01047. PMID 14998926. 

Further reading