- OSM-9
-
OSMotic avoidance abnormal family member (osm-9) (Caenorhabditis elegans) Identifiers Symbol OSM-9 Entrez 177117 Other data OSM-9 also known as OSMotic avoidance abnormal family member 9 is a protein which in the nematode worm C. elegans is encoded by the osm-9 gene.[1]
Function
The OSM-9 protein is required for some olfactory and osmotic stimuli as well as a mechanosensory response to nose touch. This protein encodes a protein with ankyrin repeats and is closely related in sequence to the mammalian TRPV ion channels.[1] OSM-9 controls the biosynthesis of serotonin via regulation of the expression of the enzyme tryptophan hydroxylase.[2]
References
- ^ a b Colbert HA, Smith TL, Bargmann CI (November 1997). "OSM-9, a novel protein with structural similarity to channels, is required for olfaction, mechanosensation, and olfactory adaptation in Caenorhabditis elegans". J. Neurosci. 17 (21): 8259–69. PMID 9334401. http://www.jneurosci.org/cgi/pmidlookup?view=long&pmid=9334401.
- ^ Zhang S, Sokolchik I, Blanco G, Sze JY (April 2004). "Caenorhabditis elegans TRPV ion channel regulates 5HT biosynthesis in chemosensory neurons". Development 131 (7): 1629–38. doi:10.1242/dev.01047. PMID 14998926.
Further reading
- Kahn-Kirby AH, Bargmann CI (2006). "TRP channels in C. elegans". Annu. Rev. Physiol. 68 (1): 719–36. doi:10.1146/annurev.physiol.68.040204.100715. PMID 16460289. http://arjournals.annualreviews.org/doi/abs/10.1146/annurev.physiol.68.040204.100715?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dncbi.nlm.nih.gov.
This protein-related article is a stub. You can help Wikipedia by expanding it.
