OSM may refer to:
- OpenStreetMap, a collaborative, open source project to develop free geographic data
- Honda OSM, a concept car manufactured by Honda
- Oncostatin M, a protein
- Montreal Symphony Orchestra (Orchestre symphonique de Montréal), a symphony orchestra based in Montreal, Quebec, Canada
- Office of Surface Mining, part of the United States Department of the Interior
- Operational Service Medal, a British Armed Forces campaign medal
- Order of the Servants of Mary, a member of the Servite Order
- Mosul International Airport (IATA airport code), located at Mosul, Iraq
- Disney's One Saturday Morning's acronym
Osm may refer to:
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