Naphthylvinylpyridine

Naphthylvinylpyridine
Naphthylvinylpyridine
IUPAC name
4-[(E)-2-naphthalen-1-ylethenyl]pyridine
Identifiers
CAS number 16375-56-7
PubChem 5475238
Jmol-3D images Image 1
Properties
Molecular formula C17H13N
Molar mass 231.29 g/mol
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Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Naphthylvinylpyridine (NVP) is a naphthalene derivative that possesses anticholinergic activity similar to that of atropine. However, NVP's method of acetylcholine (ACh) antagonism involves inhibiting the enzyme choline acetyltransferase.[1]

Several NVP derivatives have been synthesized and evaluated for their ability to inhibit choline acetyltransferase and protect against nerve toxins.[2][3]

References

  1. ^ Haubrich, DR; Goldberg, ME (1975). "Homovanillic acid concentration in the rat brain: Effect of a choline acetyltransferase inhibitor and comparison with cholinergic and dopaminergic agents". Neuropharmacology (Squibb Institute for Medical Research) 14 (3): 211–214. doi:10.1016/0028-3908(75)90007-6. PMID 1134625. http://www.sciencedirect.com/science/article/pii/0028390875900076. Retrieved July 2011. 
  2. ^ Cozzari, Costantino; Hartman, BK (1983). "Synthesis of a naphthylvinylpyridine derivative and its use for affinity chromatography of choline acetyltransferase". Analytical Biochemistry (Department of Psychiatry and Neurobiology, Washington University School of Medicine) 133 (1): 120–125. doi:10.1016/0003-2697(83)90231-2. http://www.sciencedirect.com/science/article/pii/0003269783902312. Retrieved July 2011. 
  3. ^ Gray, AP; Henderson, TR (1988). "Approaches to protection against nerve agent poisoning". J Med Chem (Dynamac Corporation) 31 (4): 807–814. PMID 3351860. 


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