Notch proteins

Notch (DSL) domain
Structure of a Prototype LNR Module from Human Notch1.[1]
Identifiers
Symbol	Notch
Pfam	PF00066
InterPro	IPR000800
SMART	SM00004
PROSITE	PS50258
Available protein structures: Pfam structures PDB RCSB PDB; PDBe PDBsum structure summary

Notch (DSL) proteins are a family of transmembrane proteins with repeated extracellular EGF domains and the notch (or DSL) domains. These proteins are involved in lateral inhibition in embryogenesis.

The Notch signaling network is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells. In Drosophila, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development.^[2]

Human proteins containing this domain

Notch-1

Main article: Notch-1

This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells. In Drosophila, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development.^[3] A deficiency can be associated with bicuspid aortic valve.^[4]

There is evidence that activated Notch 1 and Notch 3 promote differentiation of progenitor cells into astroglia.^[5] Interestingliy, Notch 1, then activated before birth, induces radial glia differentiation,^[6] but postnatally induces the differentiation into astrocytes.^[7] One study shows that Notch-1 cascade is activated by Reelin in an unidentified way.^[8] Reelin and Notch1 cooperate in the development of the dentate gyrus, according to another.^[9]

Notch-2

Main article: Notch-2

Notch-2 (Neurogenic locus notch homolog protein 2) is a protein that in humans is encoded by the NOTCH2 gene.^[10]

NOTCH2 is associated with Alagille syndrome^[11] and Hajdu–Cheney syndrome.^[12]

Notch-3

Main article: NOTCH3

Notch-4

Main article: NOTCH4

See also

• Notch signaling pathway

Notes

1. ^ Vardar D, North CL, Sanchez-Irizarry C, Aster JC, Blacklow SC (June 2003). "Nuclear magnetic resonance structure of a prototype Lin12-Notch repeat module from human Notch1". Biochemistry 42 (23): 7061–7. doi:10.1021/bi034156y. PMID 12795601. 
2. ^ "Entrez Gene: NOTCH2 Notch homolog 2 (Drosophila)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4853. 
3. ^ "Entrez Gene: NOTCH1 Notch homolog 1, translocation-associated (Drosophila)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4851. 
4. ^ Stephen H. McKellar MD (August 2007). "Novel NOTCH1 mutations in patients with bicuspid aortic valve disease and thoracic aortic aneurysms". J Thorac Cardiovasc Surg 134 (2): 290–296. doi:10.1016/j.jtcvs.2007.02.041. PMID 17662764. 
5. ^ Tanigaki K, Nogaki F, Takahashi J, Tashiro K, Kurooka H, Honjo T (January 2001). "Notch1 and Notch3 instructively restrict bFGF-responsive multipotent neural progenitor cells to an astroglial fate". Neuron 29 (1): 45–55. doi:10.1016/S0896-6273(01)00179-9. PMID 11182080. http://linkinghub.elsevier.com/retrieve/pii/S0896-6273(01)00179-9. 
6. ^ Gaiano N, Nye JS, Fishell G (May 2000). "Radial glial identity is promoted by Notch1 signaling in the murine forebrain". Neuron 26 (2): 395–404. doi:10.1016/S0896-6273(00)81172-1. PMID 10839358. http://linkinghub.elsevier.com/retrieve/pii/S0896-6273(00)81172-1. 
7. ^ Chambers CB, Peng Y, Nguyen H, Gaiano N, Fishell G, Nye JS (March 2001). "Spatiotemporal selectivity of response to Notch1 signals in mammalian forebrain precursors". Development 128 (5): 689–702. PMID 11171394. http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=11171394. 
8. ^ Keilani S, Sugaya K (July 2008). "Reelin induces a radial glial phenotype in human neural progenitor cells by activation of Notch-1". BMC Dev. Biol. 8 (1): 69. doi:10.1186/1471-213X-8-69. PMC 2447831. PMID 18593473. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2447831. 
9. ^ Sibbe M, Förster E, Basak O, Taylor V, Frotscher M (July 2009). "Reelin and Notch1 cooperate in the development of the dentate gyrus". J. Neurosci. 29 (26): 8578–85. doi:10.1523/JNEUROSCI.0958-09.2009. PMID 19571148. 
10. ^ Larsson C, Lardelli M, White I, Lendahl U (May 1995). "The human NOTCH1, 2, and 3 genes are located at chromosome positions 9q34, 1p13-p11, and 19p13.2-p13.1 in regions of neoplasia-associated translocation". Genomics 24 (2): 253–8. doi:10.1006/geno.1994.1613. PMID 7698746. 
11. ^ Samejima H, Torii C, Kosaki R, et al. (2007). "Screening for Alagille syndrome mutations in the JAG1 and NOTCH2 genes using denaturing high-performance liquid chromatography". Genet. Test. 11 (3): 216–27. doi:10.1089/gte.2006.0519. PMID 17949281. 
12. ^ Simpson, MA; Irving, MD, Asilmaz, E, Gray, MJ, Dafou, D, Elmslie, FV, Mansour, S, Holder, SE, Brain, CE, Burton, BK, Kim, KH, Pauli, RM, Aftimos, S, Stewart, H, Kim, CA, Holder-Espinasse, M, Robertson, SP, Drake, WM, Trembath, RC (2011-03-06). "Mutations in NOTCH2 cause Hajdu-Cheney syndrome, a disorder of severe and progressive bone loss.". Nature genetics 43 (4): 303–5. doi:10.1038/ng.779. PMID 21378985. 

References

• Tax FE, Yeargers JJ, Thomas JH (1994;). "Sequence of C. elegans lag-2 reveals a cell-signalling domain shared with Delta and Serrate of Drosophila". Nature (368): 150–154.  PubMed
• Lindsell CE, Shawber CJ, Boulter J, Weinmaster G (1995). "Jagged: a mammalian ligand that activates Notch1". Cell (80): 909–917.  {PMID|7697721}}
• Kelley MR, Kidd S, Deutsch WA, Young MW (1987). "Mutations altering the structure of epidermal growth factor-like coding sequences at the Drosophila Notch locus". Cell (51): 539–548.  PubMed

This membrane protein-related article is a stub. You can help Wikipedia by expanding it.v · public domain Pfam and InterPro IPR000800 Wikimedia Foundation. 2010. Игры ⚽ Нужно решить контрольную? Notch-2 Night of the Day of the Dawn of the Son of the Bride of the Return of the Revenge of the Terror of the Attack of the Evil, Mutant, Alien, Flesh Eating, Hellbound, Zombified Living Dead Part 2: In Shocking 2-D Look at other dictionaries: Notch signaling pathway — Structure of the ligand binding region of the human NOTCH 1 receptor …   Wikipedia Notch-2 — PDB rendering based on 2oo4 …   Wikipedia Notch 3 — Identifiers Symbols NOTCH3; CADASIL; CASIL External IDs OMIM:  …   Wikipedia Notch-1 — HN1 redirects here. For the nitrogen mustard, see Bis(2 chloroethyl)ethylamine. Notch 1 PDB rendering based on 1pb5 …   Wikipedia Notch — Family of large transmembrane receptor proteins (350 kD) that mediate developmental cell fate decisions; Notch contains 36 repeats of the EGF like domain. Mammalian Notch gene mutations have been associated with leukaemia, breast cancer, stroke… …   Dictionary of molecular biology MamL-1 domain — MamL 1 Identifiers Symbol MamL 1 Pfam PF09596 InterPro IPR019082 …   Wikipedia HES5 — Hairy and enhancer of split 5 (Drosophila), also known as HES5, is a human gene.cite web | title = Entrez Gene: HES5 hairy and enhancer of split 5 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView… …   Wikipedia NOTCH4 — Notch 4 Identifiers Symbols NOTCH4; FLJ16302; INT3; MGC74442; NOTCH3 External IDs OM …   Wikipedia NOTCH2 — Notch homolog 2 (Drosophila), also known as NOTCH2, is a human gene.NOTCH2 is associated with Alagille syndrome.cite journal |author=Samejima H, Torii C, Kosaki R, et al |title=Screening for Alagille syndrome mutations in the JAG1 and NOTCH2… …   Wikipedia Cell signaling — is part of a complex system of communication that governs basic cellular activities and coordinates cell actions. [Witzany, G. (2000). Life: The Communicative Structure. Norderstedt, Libri BoD.] The ability of cells to perceive and correctly… …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”