Motexafin lutetium

Motexafin lutetium
Other names Antrin; Lu texaphyrin; Lu-Tex; Lutetium texaphyrin; Lutrin; Optrin; PCI 0123
Identifiers
CAS number	246252-04-0
PubChem	3081907
Jmol-3D images	Image 1
SMILES CC([O-])=O.CCC1=C2[N-]C(/C=C3N=C(/C=N/C4=CC(OCCOCCOCCOC)=C(OCCOCCOCCOC)C=C4/N=C/C(C(C)=C/5CCCO)=[N]([Lu+3])C5=C/2)C(C)=C\3CCCO)=C1CC
Properties
Molecular formula	C52H72LuN5O14
Molar mass	1166.12 g mol−1
Y (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Motexafin lutetium is a texaphyrin, marketed as Antrin by Pharmacyclics Inc.

It is a photosensitiser for use in photodynamic therapy to treat skin conditions and superficial cancers.

It has also been tested for use in photoangioplasty (photodynamic treatment of diseased arteries).^[1]

It is photoactivated by 732 nm light which allows greater depth of penetration.^[2]

Clinical trials

Phase II clinical trials were in progress in 1999.^[3]

A phase I trial for prostate cancer reported in 2009.^[4]

References

1. ^ Pharmacyclics Announces Final Phase 1 Results of Antrin Phototherapy For Coronary Artery Disease, 2002
2. ^ http://findarticles.com/p/articles/mi_qa3931/is_200909/ai_n42040200/pg_9/ Porphyrin and Nonporphyrin Photosensitizers in Oncology: Preclinical and Clinical Advances in Photodynamic Therapy Photochemistry and Photobiology, Sep/Oct 2009. by O'Connor, Aisling E, Gallagher, William M, Byrne, Annette T
3. ^ Antrin® Photoangioplasty Phase II Clinical Trial Patient Treated During Live Case Demonstration at TCT, 1999
4. ^ Patel, H; Mick, R; Finlay, J; Zhu, TC; Rickter, E; Cengel, KA; Malkowicz, SB; Hahn, SM et al. (2008). "Motexafin lutetium-photodynamic therapy of prostate cancer: Short and long term effects on PSA". Clinical cancer research : an official journal of the American Association for Cancer Research 14 (15): 4869–76. doi:10.1158/1078-0432.CCR-08-0317. PMC 2680073. PMID 18676760. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2680073. 

This dermatologic drug article is a stub. You can help Wikipedia by expanding it.v · Categories: Tetrapyrroles Lutetium compounds Dermatologic drug stubs Wikimedia Foundation. 2010. Игры ⚽ Нужно сделать НИР? Ave verum corpus (Mozart) Motezuma (Mysliveček) Look at other dictionaries: motexafin lutetium — A substance that is being studied in the treatment of cancer using photodynamic therapy. It belongs to the family of drugs called metallotexaphyrins. Also called lutetium texaphyrin …   English dictionary of cancer terms lutetium texaphyrin — A substance that is being studied in the treatment of cancer using photodynamic therapy. It belongs to the family of drugs called metallotexaphyrins. Also called motexafin lutetium …   English dictionary of cancer terms List of oncology-related terms — This is a list of terms related to oncology. The original source for this list was the U.S. National Cancer Institute s public domain Dictionary of Cancer Terms . NOTOC 1 * 10 propargyl 10 deazaaminopterin * 12 O tetradecanoylphorbol 13 acetate * …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”