Mitochondrial fission factor

Mitochondrial fission factor
mitochondrial fission factor
Identifiers
Symbols MFF; GL004; MGC110913; DKFZp666J168; C2orf33
External IDs MGI: 1922984 HomoloGene: 87000 GeneCards: MFF Gene
Orthologs
Species Human Mouse
Entrez 56947 75734
Ensembl ENSG00000168958 ENSMUSG00000026150
UniProt Q9GZY8 Q6PCP5
RefSeq (mRNA) NM_020194 NM_029409
RefSeq (protein) NP_064579 NP_083685
Location (UCSC) Chr 2:
227.9 – 227.93 Mb		 Chr 1:
82.72 – 82.75 Mb
PubMed search [1] [2]

Mitochondrial fission factor (Mff) is a protein that in humans is encoded by the MFF gene.[1]

Mff is an outer mitochondrial membrane protein that binds to the Drp1 GTPase that controls mitochondrial fission. The Mff-Drp1 complex promotes mitochondrial fission.[2] Mff also regulates peroxisome morphology.[3]

References

  1. ^ "Entrez Gene: mitochondrial fission factor". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56947. 
  2. ^ Otera, H.; Wang, C.; Cleland, M. M.; Setoguchi, K.; Yokota, S.; Youle, R. J.; Mihara, K. (2010). "Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells". The Journal of Cell Biology 191 (6): 1141–1158. doi:10.1083/jcb.201007152. PMC 3002033. PMID 21149567. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3002033.  edit
  3. ^ Gandre-Babbe, S.; Van Der Bliek, A. M. (2008). "The Novel Tail-anchored Membrane Protein Mff Controls Mitochondrial and Peroxisomal Fission in Mammalian Cells". Molecular Biology of the Cell 19 (6): 2402–2412. doi:10.1091/mbc.E07-12-1287. PMC 2397315. PMID 18353969. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2397315.  edit

Further reading

  • Igci YZ, Arslan A, Akarsu E, et al. (2011). "Differential expression of a set of genes in follicular and classic variants of papillary thyroid carcinoma.". Endocr. Pathol. 22 (2): 86–96. doi:10.1007/s12022-011-9157-8. PMID 21509594. 

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