Minodronic acid

Minodronic acid: Minodronic acid

IUPAC name

(1-Hydroxy-2-imidazo[1,2-a]pyridin-3-yl-1-phosphonoethyl)phosphonic acid

Other names

Minodronate; YM 529

Identifiers

CAS number 180064-38-4^Y, 155648-60-5 (hydrate)^Y

PubChem 130956

ChemSpider 115805^Y

Jmol-3D images Image 1

SMILES

O=P(O)(O)C(O)(P(=O)(O)O)Cc1cnc2ccccn12

InChI

InChI=1S/C9H12N2O7P2/c12-9(19(13,14)15,20(16,17)18)5-7-6-10-8-3-1-2-4-11(7)8/h1-4,6,12H,5H2,(H2,13,14,15)(H2,16,17,18)^Y
Key: VMMKGHQPQIEGSQ-UHFFFAOYSA-N^N

Properties

Molecular formula C₉H₁₂N₂O₇P₂

Molar mass 322.15 g mol⁻¹

N acid (verify) (what is: Y/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)

Infobox references

Minodronic acid is a third-generation bisphosphonate drug. It is approved for use in Japan for the treatment of osteoporosis.^[1] Its mechanism of action involves inhibition of farnesyl pyrophosphate synthase activity.^[2]

References

^ Shridhar Hegde and Michelle Schmidt (2009). "To Market, To Market - 2009. 16. Minodronic acid". Annual Reports in Medicinal Chemistry 45: 509–510.

^ Sorbera, L.A.; Castañer, J.; Leeson, P.A. (2002). "Minodronic Acid". Drugs of the Future 27 (10): 935–941. doi:10.1358/dof.2002.027.10.701186.

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Academic Dictionaries and Encyclopedias

Minodronic acid

IUPAC name (1-Hydroxy-2-imidazo[1,2-a]pyridin-3-yl-1-phosphonoethyl)phosphonic acid
Other names Minodronate; YM 529
Identifiers
CAS number	180064-38-4^Y, 155648-60-5 (hydrate)^Y
PubChem	130956
ChemSpider	115805^Y
Jmol-3D images	Image 1
SMILES O=P(O)(O)C(O)(P(=O)(O)O)Cc1cnc2ccccn12
InChI InChI=1S/C9H12N2O7P2/c12-9(19(13,14)15,20(16,17)18)5-7-6-10-8-3-1-2-4-11(7)8/h1-4,6,12H,5H2,(H2,13,14,15)(H2,16,17,18)^Y Key: VMMKGHQPQIEGSQ-UHFFFAOYSA-N^N
Properties
Molecular formula	C₉H₁₂N₂O₇P₂
Molar mass	322.15 g mol⁻¹
N acid (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references