- Mga (protein)
-
Mga Identifiers Symbol Mga Pfam PF05043 Pfam clan CL0123 InterPro IPR007737 Available protein structures: Pfam structures PDB RCSB PDB; PDBe PDBsum structure summary Mga is a DNA-binding protein that activates the expression of several important virulence genes in Streptococcus pyogenes (group A Streptococcus, GAS) in response to changing environmental conditions.[1] The family also contains VirR like proteins which match only at the C-terminus.
Mga is a wide-reaching regulator, affecting gene expression in over 10% of the S. pyrogenes genome.[2] The other large regulator of virulence in GAS is the CovR/S two-component system, which affects the expression of approximately 15% of the genome.[3] The two systems are linked through another protein, RivR, and a small non-coding RNA RivX.[4]
References
- ^ McIver KS, Myles RL (March 2002). "Two DNA-binding domains of Mga are required for virulence gene activation in the group A streptococcus". Mol. Microbiol. 43 (6): 1591–601. doi:10.1046/j.1365-2958.2002.02849.x. PMID 11952907.
- ^ Hondorp, ER; McIver, KS (2007 Dec). "The Mga virulence regulon: infection where the grass is greener.". Molecular microbiology 66 (5): 1056–65. doi:10.1111/j.1365-2958.2007.06006.x. PMID 18001346.
- ^ Churchward, G (2007 Apr). "The two faces of Janus: virulence gene regulation by CovR/S in group A streptococci.". Molecular microbiology 64 (1): 34–41. doi:10.1111/j.1365-2958.2007.05649.x. PMID 17376070.
- ^ Roberts, SA; Scott, JR (2007 Dec). "RivR and the small RNA RivX: the missing links between the CovR regulatory cascade and the Mga regulon.". Molecular microbiology 66 (6): 1506–22. doi:10.1111/j.1365-2958.2007.06015.x. PMID 18005100.
This article includes text from the public domain Pfam and InterPro IPR007737
Categories:- Protein domains
- DNA-binding proteins
Wikimedia Foundation. 2010.
