Methylamine—glutamate N-methyltransferase

Methylamine—glutamate N-methyltransferase
methylamine-glutamate N-methyltransferase
Identifiers
EC number 2.1.1.21
CAS number 9045-32-3
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a methylamine-glutamate N-methyltransferase (EC 2.1.1.21) is an enzyme that catalyzes the chemical reaction

methylamine + L-glutamate \rightleftharpoons NH3 + N-methyl-L-glutamate

Thus, the two substrates of this enzyme are methylamine and L-glutamate, whereas its two products are NH3 and N-methyl-L-glutamate.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is methylamine:L-glutamate N-methyltransferase. Other names in common use include N-methylglutamate synthase, and methylamine-glutamate methyltransferase. This enzyme participates in methane metabolism.

References

  • Shaw WV, Tsai L, Stadtman ER (1966). "The enzymatic synthesis of N-methylglutamic acid". J. Biol. Chem. 241 (4): 935–45. PMID 5905132. 
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