- Methanol—5-hydroxybenzimidazolylcobamide Co-methyltransferase
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methanol-5-hydroxybenzimidazolylcobamide Co-methyltransferase Identifiers EC number 2.1.1.90 CAS number 86611-98-5 Databases IntEnz IntEnz view BRENDA BRENDA entry ExPASy NiceZyme view KEGG KEGG entry MetaCyc metabolic pathway PRIAM profile PDB structures RCSB PDB PDBe PDBsum Gene Ontology AmiGO / EGO Search PMC articles PubMed articles In enzymology, a methanol-5-hydroxybenzimidazolylcobamide Co-methyltransferase (EC 2.1.1.90) is an enzyme that catalyzes the chemical reaction
- methanol + 5-hydroxybenzimidazolylcobamide
Co-methyl-Co-5-hydroxybenzimidazolylcob(I)amide + H2O
Thus, the two substrates of this enzyme are methanol and 5-hydroxybenzimidazolylcobamide, whereas its two products are Co-methyl-Co-5-hydroxybenzimidazolylcob(I)amide and H2O.
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is methanol:5-hydroxybenzimidazolylcobamide Co-methyltransferase. Other names in common use include methanol cobalamin methyltransferase, methanol:5-hydroxybenzimidazolylcobamide methyltransferase, and MT 1.
Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2I2X.
References
- Vogels GD; Te Brömmelstroet, BW; Poirot, CM; Van Der Drift, C; Vogels, GD (1984). "Purification and properties of methanol:5-hydroxybenzimidazolylcobamide methyltransferase from Methanosarcina barkeri". J. Bacteriol. 160 (2): 629–35. PMC 214781. PMID 6438059. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=214781.
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