Methanocaldococcus jannaschii

Methanocaldococcus jannaschii

Methanocaldococcus jannaschii (formerly Methanococcus jannaschii) is a thermophilic methanogenic archaea. It was the first archaeon to have its complete genome sequenced [1] The sequencing identified many genes unique to the archaea. Many of the synthesis pathways for methanogenic cofactors were worked out biochemically in this organism,[2] as were several other archaeal-specific metabolic pathways [3]

Sequencing

Methanocaldococcus jannaschii was sequenced by a group at TIGR led by Craig Ventner [4] using whole genome shotgun sequencing. According to Ventner, the unique features of the genome provided strong evidence that there are three domains of life.[5]

References

  1. ^ Bult CJ et al. Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii. Science 273(5278):1058-73 PubMed 8688087
  2. ^ White R. Biosynthesis of the methanogenic cofactors. Vitamins and Hormones 61:299-337
  3. ^ Haase I. et al. Biosynthesis of riboflavin in Archaea. European Journal of Biochemistry 270(5):1025-1032
  4. ^ Wade N. Deep Sea Yields a Clue to Life's Origin. New York Times. August 23, 1996. link
  5. ^ Wade N. et al. ibid.

External links


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