- Vadimezan
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Vadimezan Systematic (IUPAC) name (5,6-Dimethyl-9-oxo-9H-xanthen-4-yl)-acetic acid Clinical data Pregnancy cat. ? Legal status ? Identifiers CAS number 117570-53-3 ATC code None UNII 0829J8133H Synonyms ASA404, DMXAA Chemical data Formula C17H14O4 Mol. mass 282.29 g/mol SMILES eMolecules & PubChem (what is this?) (verify) Vadimezan or ASA404 (originally DMXAA)[1] is a tumor-vascular disrupting agent (tumor-VDA) that attacks the blood supply of a cancerous tumor to cause tumor regression.[2]
Contents
Clinical trials
Non-small cell lung cancer
Vadimezan has been studied in combination with chemotherapy in at least two Phase II trials for advanced non-small cell lung cancer (NSCLC) and has shown survival extensions of around 5 months when compared to chemotherapy alone (14.0 months compared to 8.8 months).[3] [4] In April 2008, a Phase III trial started. In March 2010 the phase III trial of use as a first line therapy for NSCLC gave poor results.[5] Initerim results on another phase III trial as second-line therapy for NSCLC are due later in 2010 with the trial due to complete in 2011. In Nov 2010 the 2nd trial also gave poor interim results.[6]
Other cancers
As of February 2009[update] it is being studied for the treatment of prostate cancer[4] and HER2-negative metastatic breast cancer.[1][7]
History
ASA404 was discovered by Bruce Baguley and William Denny and their teams at the Auckland Cancer Society Research Centre at the University of Auckland in New Zealand.[7] It was licensed to Antisoma in 2001. Novartis acquired the worldwide rights for it in 2007 and it is being developed by Antisoma and Novartis.[4][7]
References
- ^ a b "New Zealand drug tested for breast-cancer fight". New Zealand Herald. 14 February 2009. http://www.nzherald.co.nz/nz/news/article.cfm?c_id=1&objectid=10556717. Retrieved 2009-02-13.
- ^ ASA404, A Novel Cancer Agent, Begins Pivotal Trial To Explore New Approach In Treating Lung Cancer, The Leading Cause Of Cancer Death, Medical News Today, 14 Apr 2008
- ^ MJ McKeage et al. (2008). "Randomised phase II study of ASA404 combined with carboplatin and paclitaxel in previously untreated advanced non-small cell lung cancer". Br J Cancer 99 (12): 2006–12. doi:10.1038/sj.bjc.6604808. PMC 2607218. PMID 19078952. http://www.nature.com/bjc/journal/v99/n12/abs/6604808a.html.
- ^ a b c ASA404 Vascular Disrupting Agent for Solid Tumours, drugdevelopment-technology.com
- ^ http://www.genengnews.com/news/bnitem.aspx?name=78979622 "Antisoma’s Shares Plummet 70% as Cancer Candidate Bombs in Phase III NSCLC Trial"
- ^ "Antisoma and Novartis Ditch ASA404 After Second Phase III NSCLC Trial Bombs". 11 Nov 2010. http://www.genengnews.com/gen-news-highlights/antisoma-and-novartis-ditch-asa404-after-second-phase-iii-nsclc-trial-bombs/81244220/.
- ^ a b c "ASA404 to be developed in breast cancer". Antisoma. 12 February 2009. http://www.antisoma.com/asm/media/press/pr2009/2009-02-12/. Retrieved 2009-02-13.
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