Vadimezan

Vadimezan
Vadimezan
Systematic (IUPAC) name
(5,6-Dimethyl-9-oxo-9H-xanthen-4-yl)-acetic acid
Clinical data
Pregnancy cat.  ?
Legal status  ?
Identifiers
CAS number 117570-53-3
ATC code None
UNII 0829J8133H YesY
Synonyms ASA404, DMXAA
Chemical data
Formula C17H14O4 
Mol. mass 282.29 g/mol
SMILES eMolecules & PubChem
 YesY(what is this?)  (verify)

Vadimezan or ASA404 (originally DMXAA)[1] is a tumor-vascular disrupting agent (tumor-VDA) that attacks the blood supply of a cancerous tumor to cause tumor regression.[2]

Contents

Clinical trials

Non-small cell lung cancer

Vadimezan has been studied in combination with chemotherapy in at least two Phase II trials for advanced non-small cell lung cancer (NSCLC) and has shown survival extensions of around 5 months when compared to chemotherapy alone (14.0 months compared to 8.8 months).[3] [4] In April 2008, a Phase III trial started. In March 2010 the phase III trial of use as a first line therapy for NSCLC gave poor results.[5] Initerim results on another phase III trial as second-line therapy for NSCLC are due later in 2010 with the trial due to complete in 2011. In Nov 2010 the 2nd trial also gave poor interim results.[6]

Other cancers

As of February 2009 it is being studied for the treatment of prostate cancer[4] and HER2-negative metastatic breast cancer.[1][7]

History

ASA404 was discovered by Bruce Baguley and William Denny and their teams at the Auckland Cancer Society Research Centre at the University of Auckland in New Zealand.[7] It was licensed to Antisoma in 2001. Novartis acquired the worldwide rights for it in 2007 and it is being developed by Antisoma and Novartis.[4][7]

References