DLEU1 (gene)

deleted in lymphocytic leukemia 1 (non-protein coding)
Identifiers
Symbols	DLEU1; XTP6; LEU2; LEU1; MGC22430; DLEU2; DLB1; NCRNA00021; BCMS
External IDs	OMIM: 605765 GeneCards: DLEU1 Gene
Gene Ontology
Orthologs
Species	Human	Mouse
Entrez	10301	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	NR_002605	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	[1]	n/a

In molecular biology, deleted in lymphocytic leukemia 1 (non-protein coding), also known as DLEU1, is a long non-coding RNA. In humans it is located on chromosome 13q14. The DLEU1 gene was originally identified as a potential tumour suppressor gene and is often deleted in patients with B-cell chronic lymphocytic leukemia.^[1] It was later discovered to be a long non-coding RNA with over 20 different splice variants.^[2]

See also

• Long noncoding RNA

References

1. ^ Liu Y, Corcoran M, Rasool O, Ivanova G, Ibbotson R, Grandér D et al. (1997). "Cloning of two candidate tumor suppressor genes within a 10 kb region on chromosome 13q14, frequently deleted in chronic lymphocytic leukemia.". Oncogene 15 (20): 2463–73. doi:10.1038/sj.onc.1201643. PMID 9395242. 
2. ^ Wolf S, Mertens D, Schaffner C, Korz C, Döhner H, Stilgenbauer S et al. (2001). "B-cell neoplasia associated gene with multiple splicing (BCMS): the candidate B-CLL gene on 13q14 comprises more than 560 kb covering all critical regions.". Hum Mol Genet 10 (12): 1275–85. doi:10.1093/hmg/10.12.1275. PMID 11406609. 

Further reading

• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070. 
• Kapanadze B, Makeeva N, Corcoran M, et al. (2000). "Comparative sequence analysis of a region on human chromosome 13q14, frequently deleted in B-cell chronic lymphocytic leukemia, and its homologous region on mouse chromosome 14.". Genomics 70 (3): 327–34. doi:10.1006/geno.2000.6386. PMID 11161783. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Mertens D, Philippen A, Ruppel M, et al. (2009). "Chronic lymphocytic leukemia and 13q14: miRs and more.". Leuk. Lymphoma 50 (3): 502–5. doi:10.1080/10428190902763509. PMID 19347735. 
• Polasek O, Marusić A, Rotim K, et al. (2009). "Genome-wide association study of anthropometric traits in Korcula Island, Croatia.". Croat. Med. J. 50 (1): 7–16. PMID 19260139.