DAOA-AS1

DAOA antisense RNA 1 (non-protein coding)
Identifiers
Symbols	DAOA-AS1; DAOA-AS; DAOAAS; G30
External IDs	OMIM: 607415 GeneCards: DAOA-AS1 Gene
Gene Ontology
Orthologs
Species	Human	Mouse
Entrez	282706	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	[1]	n/a

In molecular biology, DAOA-AS1 ,DAOA antisense RNA 1 (non-protein coding), (formerly known as known as G30), is a human gene encoding a long non-coding RNA. It was originally identified in a screen for genes associated with schizophrenia.^[1] It is also associated with bipolar disorder and other psychiatric phenotypes.^[2][3] It may regulate the expression of the DAOA gene.^[1]

See also

• Long non-coding RNA

References

1. ^ ^{a b} Chumakov, I.; Blumenfeld, M.; Guerassimenko, O.; Cavarec, L.; Palicio, M.; Abderrahim, H.; Bougueleret, L.; Barry, C. et al. (2002). "Genetic and physiological data implicating the new human gene G72 and the gene for d-amino acid oxidase in schizophrenia". Proceedings of the National Academy of Sciences 99 (21): 13675–13680. doi:10.1073/pnas.182412499. PMC 129739. PMID 12364586. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=129739.  edit
2. ^ Hattori, E.; Liu, C.; Badner, J. A.; Bonner, T. I.; Christian, S. L.; Maheshwari, M.; Detera-Wadleigh, S. D.; Gibbs, R. A. et al. (2003). "Polymorphisms at the G72/G30 Gene Locus, on 13q33, Are Associated with Bipolar Disorder in Two Independent Pedigree Series". The American Journal of Human Genetics 72 (5): 1131–1140. doi:10.1086/374822. PMC 1180266. PMID 12647258. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1180266.  edit
3. ^ Abou Jamra, R.; Schmael, C.; Cichon, S.; Rietschel, M.; Schumacher, J.; Nothen, M. M. (2005). "Genes and Schizophrenia: The G72/G30 Gene Locus in Psychiatric Disorders: A Challenge to Diagnostic Boundaries?". Schizophrenia Bulletin 32 (4): 599–608. doi:10.1093/schbul/sbl028. PMC 2632259. PMID 16914640. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2632259.  edit

Further reading

• Chumakov I, Blumenfeld M, Guerassimenko O, et al. (2002). "Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia.". Proc. Natl. Acad. Sci. U.S.A. 99 (21): 13675–80. doi:10.1073/pnas.182412499. PMC 129739. PMID 12364586. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=129739. 
• Hattori E, Liu C, Badner JA, et al. (2003). "Polymorphisms at the G72/G30 gene locus, on 13q33, are associated with bipolar disorder in two independent pedigree series.". Am. J. Hum. Genet. 72 (5): 1131–40. doi:10.1086/374822. PMC 1180266. PMID 12647258. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1180266. 
• Wang X, He G, Gu N, et al. (2004). "Association of G72/G30 with schizophrenia in the Chinese population.". Biochem. Biophys. Res. Commun. 319 (4): 1281–6. doi:10.1016/j.bbrc.2004.05.119. PMID 15194506. 
• Korostishevsky M, Kaganovich M, Cholostoy A, et al. (2004). "Is the G72/G30 locus associated with schizophrenia? single nucleotide polymorphisms, haplotypes, and gene expression analysis.". Biol. Psychiatry 56 (3): 169–76. doi:10.1016/j.biopsych.2004.04.006. PMID 15271585. 
• Schumacher J, Abou Jamra R, Becker T, et al. (2005). "Investigation of the DAOA/G30 locus in panic disorder.". Mol. Psychiatry 10 (5): 428–9. doi:10.1038/sj.mp.4001598. PMID 15477870. 
• Britten RJ (2005). "Coding sequences of functioning human genes derived entirely from mobile element sequences.". Proc. Natl. Acad. Sci. U.S.A. 101 (48): 16825–30. doi:10.1073/pnas.0406985101. PMC 534736. PMID 15546984. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=534736. 
• Zou F, Li C, Duan S, et al. (2005). "A family-based study of the association between the G72/G30 genes and schizophrenia in the Chinese population.". Schizophrenia Research 73 (2–3): 257–61. doi:10.1016/j.schres.2004.01.015. PMID 15653269. 
• Mulle JG, McDonough JA, Chowdari KV, et al. (2005). "Evidence for linkage to chromosome 13q32 in an independent sample of schizophrenia families". Mol. Psychiatry 10 (5): 429–31. doi:10.1038/sj.mp.4001639. PMID 15738936. 
• Ma J, Qin W, Wang XY, et al. (2006). "Further evidence for the association between G72/G30 genes and schizophrenia in two ethnically distinct populations". Mol. Psychiatry 11 (5): 479–87. doi:10.1038/sj.mp.4001788. PMID 16402132. 
• Hong CJ, Hou SJ, Yen FC, et al. (2006). "Family-based association study between G72/G30 genetic polymorphism and schizophrenia". Neuroreport 17 (10): 1067–9. doi:10.1097/01.wnr.0000224763.61959.26. PMID 16791105. 
• Li D, He L (2007). "G72/G30 genes and schizophrenia: a systematic meta-analysis of association studies". Genetics 175 (2): 917–22. doi:10.1534/genetics.106.061796. PMC 1800627. PMID 17179078. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1800627. 
• Yue W, Liu Z, Kang G, et al. (2007). "Association of G72/G30 polymorphisms with early-onset and male schizophrenia". Neuroreport 17 (18): 1899–902. doi:10.1097/WNR.0b013e3280102ed4. PMID 17179866. 

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