Cyclic pyranopterin monophosphate

Cyclic pyranopterin monophosphate
Other names cPMP; Precursor Z
Identifiers
CAS number	150829-29-1 Y
PubChem	25202908
Jmol-3D images	Image 1
SMILES O=C(N=C(N)N1)C(N2)=C1NC(O3)C2C(O)(O)C(O4)C3COP4(O)=O
Properties
Molecular formula	C10H14N5O8P
Molar mass	363.22 g mol−1
Y (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Cyclic pyranopterin monophosphate (cPMP) is an experimental treatment for molybdenum cofactor deficiency type A, which was developed by the pioneering work of Jose Santamaría-Araujo, PhD and Prof.Dr. Schwarz at the german universities TU Braunschweig and the University of Cologne.^[1][2]

cPMP is a precursor to molybdenum cofactor, which is required for the enyzme activity of sulfite oxidase, xanthine dehydrogenase/oxidase and aldehyde oxidase.^[3]

External links

• Guenter Schwarz Laboratory, Institute for Biochemistry - University of Cologne (english, german)

References

1. ^ Günter Schwarz, José Angel Santamaria-Araujo, Stefan Wolf, Heon-Jin Lee, Ibrahim M. Adham, Hermann-Josef Gröne, Herbert Schwegler, Jörn Oliver Sass, Tanja Otte, Petra Hänzelmann, Ralf R. Mendel, Wolfgang Engel and Jochen Reiss (2004). "Rescue of lethal molybdenum cofactor deficiency by a biosynthetic precursor from Escherichia coli". Human Molecular Genetics 13 (12): 1249–1255. doi:10.1093/hmg/ddh136. PMID 15115759. http://hmg.oxfordjournals.org/cgi/content/full/13/12/1249. 
2. ^ Doctors risk untried drug to stop baby’s brain dissolving, TimesOnline, November 5, 2009
3. ^ José Angel Santamaria-Araujo, Berthold Fischer, Tanja Otte, Manfred Nimtz, Ralf R. Mendel, Victor Wray and Günter Schwarz (2004). "The Tetrahydropyranopterin Structure of the Sulfur-free and Metal-free Molybdenum Cofactor Precursor". The Journal of Biological Chemistry 279 (16): 15994–15999. doi:10.1074/jbc.M311815200. PMID 14761975. http://www.jbc.org/content/279/16/15994.long. 

This pharmacology-related article is a stub. You can help Wikipedia by expanding it.v · Categories: Pharmacology stubs Organophosphates Wikimedia Foundation. 2010. Игры ⚽ Нужен реферат? Cyclic polytope Cyclic salt Look at other dictionaries: CPMP — may refer to: Committee for Proprietary Medicinal Products Certified Project Management Professional Core Plus Mathematics Project Cyclic pyranopterin monophosphate Commissioning Process Management Professional (ASHRAE) This disambiguation page… …   Wikipedia Molybdenum cofactor deficiency — Classification and external resources OMIM 252150 DiseasesDB 29905 eMedicine …   Wikipedia Molybdopterin synthase — is an enzyme required to sythesize molybdenum cofactor (MoCo) from precursor Z (now known as cyclic pyranopterin monophosphate). It is heterodimeric and coded for by the MOCS2 gene.[1] References ^ Sloan, J; Kinghorn, JR; Unkles, SE (1999). The… …   Wikipedia Molybdopterin — Identifiers CAS number 73508 07 3  …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”