Condensation domain

Condensation
crystal structure of vibh, an nrps condensation enzyme
Identifiers
Symbol	Condensation
Pfam	PF00668
Pfam clan	CL0149
InterPro	IPR001242
SCOP	1l5a
Available protein structures: Pfam structures PDB RCSB PDB; PDBe PDBsum structure summary

In molecular biology, the condensation domain is a protein domain found in many multi-domain enzymes which synthesise peptide antibiotics. This domain catalyses a condensation reaction to form peptide bonds in non-ribosomal peptide biosynthesis. It is usually found to the carboxy side of a phosphopantetheine binding domain (pp-binding). It has been shown that mutations in the HHXXXDG sequence motif in this domain abolish activity suggesting this is part of the active site.^[1]

References

1. ^ Stachelhaus T, Mootz HD, Bergendahl V, Marahiel MA (August 1998). "Peptide bond formation in nonribosomal peptide biosynthesis. Catalytic role of the condensation domain". J. Biol. Chem. 273 (35): 22773–81. PMID 9712910. 

This article includes text from the public domain Pfam and InterPro IPR001242