Cohesin domain

Cohesin
single cohesin domain from the scaffolding protein cipa of the clostridium thermocellum cellulosome
Identifiers
Symbol	Cohesin
Pfam	PF00963
Pfam clan	CL0203
InterPro	IPR002102
SCOP	1anu
Available protein structures: Pfam structures PDB RCSB PDB; PDBe PDBsum structure summary

In molecular biology, the cohesin domain is a protein domain. It interacts with a complementary domain, termed the dockerin domain. The cohesin-dockerin interaction is the crucial interaction for complex formation in the cellulosome.^[1]

The scaffoldin component of the cellulolytic bacterium Clostridium thermocellum is a non-hydrolytic protein which organises the hydrolytic enzymes into a large complex, called the cellulosome. Scaffoldin comprises a series of functional domains, amongst which is a single cellulose-binding domain and nine cohesin domains which are responsible for integrating the individual enzymatic subunits into the complex.

References

1. ^ Shimon LJ, Bayer EA, Morag E, Lamed R, Yaron S, Shoham Y, Frolow F (March 1997). "A cohesin domain from Clostridium thermocellum: the crystal structure provides new insights into cellulosome assembly". Structure 5 (3): 381–90. PMID 9083107. 

This article includes text from the public domain Pfam and InterPro IPR002102