Chymopapain

Chymopapain

Clinical data
Pregnancy cat.	?
Legal status	℞ Prescription only
Routes	Injection into intervertebral disc
Identifiers
ATC code	M09AB01
UNII	1UK146T40N N
ChEMBL	CHEMBL1201626 N
Chemical data
Formula	?
N(what is this?)  (verify)

Chymopapain (trand name Chymodiactin) is a proteolytic enzyme isolated from the latex of papaya (Carica papaya), it is a medication used to treat slipped (herniated) lower lumbar discs in the spine.^[1] Chymopapain injections should preferably be given under local, rather than general, anaesthesia. The dose for a single intervertebral disc is 2 to 4 nanokatals, with a maximum dose per patient of 8 nanokatals.

The sale and distribution of chymopapain was discontinued in the United States on January 27, 2003.^[2]

Side effects

Serious side effects from the use of chymopapain include anaphylaxis, paralysis of the legs, or death.^[3]

See also

• Papain

References

1. ^ Chymopapain Injection from MedicineNet
2. ^ http://www.mayoclinic.com/health/drug-information/DR600373
3. ^ http://www.mayoclinic.com/health/drug-information/DR600373

External links

• The MEROPS online database for peptidases and their inhibitors: C01.002
• Data sheet for Papain from BIOZYM

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This enzyme-related article is a stub. You can help Wikipedia by expanding it.v · Categories: Drugs Enzymes Musculoskeletal system drug stubs Enzyme stubs Wikimedia Foundation. 2010. Игры ⚽ Нужно сделать НИР? Chylowa Huta Chymophila Look at other dictionaries: chymopapain — [kī΄mō pə pā′in, kī΄mō pəpī′in] n. papain, esp. when injected into a slipped disk to dissolve pain causing soft cartilage …   English World dictionary chymopapain — /kuy moh peuh pay in, puy in/, n. Pharm. an enzyme derived from the tropical papaya fruit that is used in some circumstances to treat herniated disks. [1970 75; CHYME + O + PAPAIN] * * * …   Universalium chymopapain — A cysteine proteinase similar to papain in specificity; on rare occasions, it is used to shrink slipped disks as an alternative to surgery; used as a meat tenderizer. It is the major endopeptidase of papaya. * * * chy·mo·pa·pa·in .kī mō pə pā ən …   Medical dictionary Chymopapain — Chy|mo|pa|pa|in [↑ Chymo u. ↑ Papain], das; s, e: aus Papayamilchsaft gewinnbare Peptidase, die med. zur ↑ Chemonukleolyse eingesetzt wird …   Universal-Lexikon chymopapain — chy·mo·papain …   English syllables chymopapain — chy•mo•pa•pa•in [[t]ˌkaɪ moʊ pəˈpeɪ ɪn, ˈpaɪ ɪn[/t]] n. biochem. an enzyme of the papaya that is capable of breaking down protein: used to dissolve cartilage in the treatment of herniated disks • Etymology: 1970–75 …   From formal English to slang chymopapain — ¦kīmōˌ noun Etymology: chyme + o + papain : a proteolytic enzyme from the latex of the papaya that is used in meat tenderizer and has been used medically in chemonucleolysis * * * /kuy moh peuh pay in, puy in/, n. Pharm. an enzyme derived from… …   Useful english dictionary chemonucleolysis — Injection of chymopapain into the nucleus pulposus of an intervertebral disk. A therapeutic option for the treatment of a herniated nucleus pulposis, e.g., “slipped disk.” * * * che·mo·nu·cle·ol·y·sis .n( …   Medical dictionary Chemonukleolyse — Che|mo|nu|k|le|o|ly|se [↑ chem , nukl (1) u. ↑ lyse], die; , n: die Auflösung des Gallertkerns von Bandscheiben (Nukleolyse) mit chem., eigtl. enzymatischen Mitteln, z. B. Chymopapain oder Kollagenase. * * * Chemonukleolyse,  … …   Universal-Lexikon List of EC numbers (EC 3) — This list contains a list of EC numbers for the third group, EC 3, hydrolases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 3.1: Acting on Ester BondsEC… …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”