Chris Ponting

Chris Ponting
Residence	England
Nationality	British
Fields	Biology
Institutions	Oxford
Alma mater	Oxford, University of British Columbia
Known for	Computational genomics

Chris P. Ponting is a British computational biologist, specializing in the evolution and function of genes and genomes. He is currently Professor of Genomics at the University of Oxford and group leader in the MRC Functional Genomics Unit, and is affiliated with the Oxford Centre for Gene Function, and Oxford's Department of Physiology, Anatomy and Genetics. After receiving his B.A. and M.Sc. in physics from Oxford and the University of British Columbia, respectively, he returned to Oxford, completing his doctorate in biophysics in 1991.^[1]

Prof. Ponting contributed to the Human Genome Project,^[2] and did much of the sequence comparison for the mouse,^[3] rat,^[4] chicken,^[5] dog,^[6] opossum,^[7] and platypus^[8] Genome Projects. He has also used comparative genomics to contribute directly to the understanding of chromatin structure^[9] and the genetics of numerous conditions including asthma,^[10] obesity,^[11] Alzheimer's disease,^[12] retinitis pigmentosa,^[13] muscular dystrophies,^[14] and Aicardi-Goutières syndrome.^[15]

References

1. ^ "Prof. Chris P Ponting BA MSc DPhil". http://www.mrcfgu.ox.ac.uk/research/chris-p-ponting. Retrieved 28 August 2009. ^{[self-published source?]}
2. ^ International Human Genome Sequencing Consortium, Lander ES, Linton LM, et al. (Feb 2001). "Initial sequencing and analysis of the human genome". Nature 409 (6822): 860–921. doi:10.1038/35057062. ISSN 0028-0836. PMID 11237011. 
3. ^ Mouse Genome Sequencing Consortium, Waterston RH, Lindblad-Toh K, et al. (Dec 2002). "Initial sequencing and comparative analysis of the mouse genome". Nature 420 (6915): 520–62. doi:10.1038/nature01262. ISSN 0028-0836. PMID 12466850. 
4. ^ Amos, Jonathan (31 March 2004). "Rat's 'life code' read by science". BBC News. http://news.bbc.co.uk/1/hi/sci/tech/3586573.stm. Retrieved 19 December 2008. 
5. ^ "Chicken gives up genetic secrets". BBC News. 9 December 2004. http://news.bbc.co.uk/1/hi/sci/tech/4079283.stm. Retrieved 19 December 2008. 
6. ^ Lindblad-Toh K, Wade CM, Mikkelsen TS, et al. (Dec 2005). "Genome sequence, comparative analysis and haplotype structure of the domestic dog". Nature 438 (7069): 803–19. doi:10.1038/nature04338. ISSN 0028-0836. PMID 16341006. 
7. ^ Mikkelsen TS, Wakefield MJ, Aken B, et al. (May 2007). "Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences". Nature 447 (7141): 167–77. doi:10.1038/nature05805. ISSN 0028-0836. PMID 17495919. 
8. ^ Briggs, Helen (7 May 2008). "Platypus genetic code unravelled". BBC News. http://news.bbc.co.uk/1/hi/sci/tech/7385949.stm. Retrieved 19 December 2008. 
9. ^ Rea S, Eisenhaber F, O'Carroll D, et al. (Aug 2000). "Regulation of chromatin structure by site-specific histone H3 methyltransferases". Nature 406 (6796): 593–9. doi:10.1038/35020506. ISSN 0028-0836. PMID 10949293. 
10. ^ Zhang Y, Leaves NI, Anderson GG, et al. (Jun 2003). "Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma". Nature genetics 34 (2): 181–6. doi:10.1038/ng1166. ISSN 1061-4036. PMID 12754510. 
11. ^ Gerken T, Girard CA, Tung YC, et al. (Nov 2007). "The Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate–Dependent Nucleic Acid Demethylase". Science 318 (5855): 1469–72. doi:10.1126/science.1151710. ISSN 0036-8075. PMC 2668859. PMID 17991826. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2668859. 
12. ^ Ponting CP, Hutton M, Nyborg A, et al. (May 2002). "Identification of a novel family of presenilin homologues" (Free full text). Human molecular genetics 11 (9): 1037–44. doi:10.1093/hmg/11.9.1037. ISSN 0964-6906. PMID 11978763. http://hmg.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=11978763. 
13. ^ Abd El-Aziz MM, Barragan I, O'Driscoll CA, et al. (Nov 2008). "EYS, encoding an ortholog of Drosophila spacemaker, is mutated in autosomal recessive retinitis pigmentosa". Nature genetics 40 (11): 1285–7. doi:10.1038/ng.241. ISSN 1061-4036. PMC 2719291. PMID 18836446. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2719291. 
14. ^ Dickens NJ, Beatson S, Ponting CP (Mar 2002). "Cadherin-like domains in alpha-dystroglycan, alpha/epsilon-sarcoglycan and yeast and bacterial proteins". Current biology 12 (6): R197–9. doi:10.1016/S0960-9822(02)00748-0. ISSN 0960-9822. PMID 11909544. 
15. ^ Crow YJ, Leitch A, Hayward BE, et al. (Aug 2006). "Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutières syndrome and mimic congenital viral brain infection". Nature genetics 38 (8): 910–6. doi:10.1038/ng1842. ISSN 1061-4036. PMID 16845400. 

External links

• Chris Ponting's homepage in the MRC Functional Genomics Unit
• Darwin 2009
• Discussing the platypus genome

Persondata
Name	Ponting, Chris
Alternative names
Short description	British computational geneticist
Date of birth
Place of birth
Date of death
Place of death