Chemerin peptides

retinoic acid receptor responder (tazarotene induced) 2
Identifiers
Symbol	RARRES2
Alt. symbols	chemerin
Entrez	5919
HUGO	9868
OMIM	601973
RefSeq	NM_002889
UniProt	Q99969
Other data
Locus	Chr. 7 q36.1

Chemerin Peptides are short peptides (on the order of 9 amino acids) that are produced from the carboxyl terminus of the chemokine chemerin. They display the same activities as chemerin ,although at higher efficacy and potency.^[1]

A particular synthetic chemerin-derived peptide, termed C15, was developed at Oxford University. It showed anti-inflammatory activities. Intraperitoneal administration of C15 (0.32 ng/kg) to mice before zymosan challenge conferred significant protection against zymosan-induced peritonitis, suppressing neutrophil (63%) and monocyte (62%) recruitment with a concomitant reduction in proinflammatory mediator expression.^[2]

C15 was found to promote phagocytosis and efferocytosis in peritoneal macrophages at picomolar concentrations. C15 enhanced macrophage clearance of microbial particles and apoptotic cells by factor of 360% in vitro ^[3]

References

1. ^ Wittamer V, Grégoire F, Robberecht P, Vassart G, Communi D, Parmentier M (March 2004). "The C-terminal nonapeptide of mature chemerin activates the chemerin receptor with low nanomolar potency". J. Biol. Chem. 279 (11): 9956–62. doi:10.1074/jbc.M313016200. PMID 14701797. 
2. ^ cash, J; Cash JL, Hart R, Russ A, Dixon JP, Colledge WH, Doran J, Hendrick AG, Carlton MB, Greaves DR (Apr 2008). "Synthetic chemerin-derived peptides suppress inflammation through ChemR23.". J Exp. Med. 205 (4): 767–75. doi:10.1084/jem.20071601. PMC 2292217. PMID 18391062. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2292217. 
3. ^ Cash, J; Greaves DR (May 2010). "Chemerin peptides promote phagocytosis in a ChemR23 and Syk dependent manner". J immuno. 184 (9): 5315–24. doi:10.4049/jimmunol.0903378. PMID 20363975. 

See also

• Chemerin
• CMKLR1
• Chemokine
• Efferocytosis