- Chemerin peptides
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retinoic acid receptor responder (tazarotene induced) 2 Identifiers Symbol RARRES2 Alt. symbols chemerin Entrez 5919 HUGO 9868 OMIM 601973 RefSeq NM_002889 UniProt Q99969 Other data Locus Chr. 7 q36.1 Chemerin Peptides are short peptides (on the order of 9 amino acids) that are produced from the carboxyl terminus of the chemokine chemerin. They display the same activities as chemerin ,although at higher efficacy and potency.[1]
A particular synthetic chemerin-derived peptide, termed C15, was developed at Oxford University. It showed anti-inflammatory activities. Intraperitoneal administration of C15 (0.32 ng/kg) to mice before zymosan challenge conferred significant protection against zymosan-induced peritonitis, suppressing neutrophil (63%) and monocyte (62%) recruitment with a concomitant reduction in proinflammatory mediator expression.[2]
C15 was found to promote phagocytosis and efferocytosis in peritoneal macrophages at picomolar concentrations. C15 enhanced macrophage clearance of microbial particles and apoptotic cells by factor of 360% in vitro [3]
References
- ^ Wittamer V, Grégoire F, Robberecht P, Vassart G, Communi D, Parmentier M (March 2004). "The C-terminal nonapeptide of mature chemerin activates the chemerin receptor with low nanomolar potency". J. Biol. Chem. 279 (11): 9956–62. doi:10.1074/jbc.M313016200. PMID 14701797.
- ^ cash, J; Cash JL, Hart R, Russ A, Dixon JP, Colledge WH, Doran J, Hendrick AG, Carlton MB, Greaves DR (Apr 2008). "Synthetic chemerin-derived peptides suppress inflammation through ChemR23.". J Exp. Med. 205 (4): 767–75. doi:10.1084/jem.20071601. PMC 2292217. PMID 18391062. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2292217.
- ^ Cash, J; Greaves DR (May 2010). "Chemerin peptides promote phagocytosis in a ChemR23 and Syk dependent manner". J immuno. 184 (9): 5315–24. doi:10.4049/jimmunol.0903378. PMID 20363975.
See also
Categories:- Genes on chromosome 7
- Biochemistry stubs
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