ERM protein family

Pfam_box
Symbol = ERM
Name = Ezrin/radixin/moesin family

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caption = Crystallographic structure of the N-terminal domain of moesin based on the PDB|1E5W coordinates.
Pfam = PF00769
InterPro= IPR011259
SMART=
PROSITE=
SCOP = 1ef1
TCDB =
OPM family =
OPM protein =
PDB = PDB2|1ef1, PDB2|1e5wThe ERM protein family consists of three closely-related proteins, ezrin,cite journal | author = Bretscher A | title = Purification of an 80,000-dalton protein that is a component of the isolated microvillus cytoskeleton, and its localization in nonmuscle cells | journal = J. Cell Biol. | volume = 97 | issue = 2 | pages = 425–32 | year = 1983 | month = August | pmid = 6885906 | pmc = 2112519 | doi = 10.1083/jcb.97.2.425 | url = | issn = ] radixincite journal | author = Tsukita S, Hieda Y, Tsukita S | title = A new 82-kD barbed end-capping protein (radixin) localized in the cell-to-cell adherens junction: purification and characterization | journal = J. Cell Biol. | volume = 108 | issue = 6 | pages = 2369–82 | year = 1989 | month = June | pmid = 2500445 | pmc = 2115614 | doi = 10.1083/jcb.108.6.2369 | url = | issn = ] and moesin.cite journal | author = Lankes W, Griesmacher A, Grünwald J, Schwartz-Albiez R, Keller R | title = A heparin-binding protein involved in inhibition of smooth-muscle cell proliferation | journal = Biochem. J. | volume = 251 | issue = 3 | pages = 831–42 | year = 1988 | month = May | pmid = 3046603 | pmc = 1149078 | doi = | url = | issn = ] cite journal | author = Tsukita S, Yonemura S, Tsukita S | title = ERM proteins: head-to-tail regulation of actin-plasma membrane interaction | journal = Trends Biochem. Sci. | volume = 22 | issue = 2 | pages = 53–8 | year = 1997 | month = February | pmid = 9048483 | doi = 10.1016/S0968-0004(96)10071-2 | url = | issn = ]

tructure

ERM molecules contain the following three domains:
* N-terminal globular domain
* extended alpha-helical domain
* charged C-terminal domain

Ezrin, radixin and merlin also contain a polyproline region between the central helical and C-terminal domains.

Function

ERM proteins crosslink actin filaments with plasma membranes. They co-localize with CD44 at actin filament-plasma membrane interaction sites, associating with CD44 via their N-terminal domains and with actin filaments via their C-terminal domains.cite journal | author = Yonemura S, Hirao M, Doi Y, Takahashi N, Kondo T, Tsukita S, Tsukita S | title = Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2 | journal = J. Cell Biol. | volume = 140 | issue = 4 | pages = 885–95 | year = 1998 | month = February | pmid = 9472040 | pmc = 2141743 | doi = 10.1083/jcb.140.4.885 | url = | issn = ]

References