Cromakalim

Cromakalim: Cromakalim

Systematic (IUPAC) name

(3R,4S)-3-hydroxy-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)chroman-6-carbonitrile

Clinical data

Pregnancy cat. ?

Legal status ?

Identifiers

CAS number 94470-67-4

ATC code None

PubChem CID 71191

ChemSpider 64327

UNII 0G4X367WA3^Y

ChEMBL CHEMBL11684

Chemical data

Formula C₁₆H₁₈N₂O₃

Mol. mass 286.32 g/mol

SMILES eMolecules & PubChem

Cromakalim (INN) is a potassium channel-opening vasodilator. The active isomer is levcromakalim. It acts on ATP-sensitive potassium channels and so causes membrane hyperpolarization. It can be used to treat hypertension as it will relax vascular smooth muscle to lower blood pressure. Hyperpolarisation of smooth muscle cell membranes pulls their membrane potential away from the threshold, so making it more difficult to excite them and thereby cause contraction.

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Systematic (IUPAC) name
(3R,4S)-3-hydroxy-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)chroman-6-carbonitrile
Clinical data
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	94470-67-4
ATC code	None
PubChem	CID 71191
ChemSpider	64327
UNII	0G4X367WA3^Y
ChEMBL	CHEMBL11684
Chemical data
Formula	C₁₆H₁₈N₂O₃
Mol. mass	286.32 g/mol
SMILES	eMolecules & PubChem