DHRS4

DHRS4: Dehydrogenase/reductase (SDR family) member 4

Identifiers

Symbols DHRS4; CR; FLJ11008; NRDR; PHCR; PSCD; SCAD-SRL; SDR-SRL; SDR25C1; SDR25C2

External IDs OMIM: 611596 MGI: 90169 HomoloGene: 49646 GeneCards: DHRS4 Gene

EC number 1.1.1.184

Gene Ontology

Molecular function • carbonyl reductase (NADPH) activity
• binding
• oxidoreductase activity

Cellular component • mitochondrion
• mitochondrion
• peroxisome
• nuclear membrane
• intracellular membrane-bounded organelle

Biological process • oxidation-reduction process

Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species Human Mouse

Entrez 10901 28200

Ensembl ENSG00000157326 ENSMUSG00000022210

UniProt Q9BTZ2 Q3UIB5

RefSeq (mRNA) NM_021004 NM_001037938

RefSeq (protein) NP_066284 NP_001033027

Location (UCSC) Chr 14:
24.42 – 24.44 Mb Chr 14:
56.1 – 56.11 Mb

PubMed search [1] [2]

Dehydrogenase/reductase SDR family member 4 is an enzyme that in humans is encoded by the DHRS4 gene.^[1]^[2]^[3]

References

^ Fransen M, Van Veldhoven PP, Subramani S (Jul 1999). "Identification of peroxisomal proteins by using M13 phage protein VI phage display: molecular evidence that mammalian peroxisomes contain a 2,4-dienoyl-CoA reductase". Biochem J 340 ( Pt 2) (Pt 2): 561–8. PMC 1220285. PMID 10333503. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1220285.

^ Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (Short-Chain Dehydrogenase/Reductase and Related Enzymes) Nomenclature Initiative". Chem Biol Interact 178 (1–3): 94–8. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2896744.

^ "Entrez Gene: DHRS4 dehydrogenase/reductase (SDR family) member 4". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10901.

Further reading

Song XH, Liang B, Liu GF et al. (2007). "Expression of a novel alternatively spliced variant of NADP(H)-dependent retinol dehydrogenase/reductase with deletion of exon 3 in cervical squamous carcinoma". Int. J. Cancer 120 (8): 1618–26. doi:10.1002/ijc.22306. PMID 17230527.

Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.

Du J, Huang DY, Liu GF et al. (2004). "CDNA cloning of a short isoform of human liver NADP (H) -dependent retinol dehydrogenase/reductase and analysis of its characteristics". Yi Chuan Xue Bao 31 (7): 661–7. PMID 15473316.

Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.

Clark HF, Gurney AL, Abaya E et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=403697.

Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.

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