PARP10

Poly (ADP-ribose) polymerase family, member 10
PDB rendering based on 2dhx.
Available structures PDB 2DHX, 3HKV
Identifiers
Symbols	PARP10; FLJ14464
External IDs	OMIM: 609564 HomoloGene: 53133 GeneCards: PARP10 Gene
EC number	2.4.2.30
Gene Ontology Molecular function • nucleotide binding • NAD+ ADP-ribosyltransferase activity • transferase activity, transferring glycosyl groups Cellular component • nucleus • nucleolus • cytoplasm • Golgi apparatus Biological process • protein amino acid ADP-ribosylation Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	84875	671535
Ensembl	ENSG00000178685	ENSMUSG00000063268
UniProt	Q53GL7	n/a
RefSeq (mRNA)	XM_001127571	n/a
RefSeq (protein)	XP_001127571	n/a
Location (UCSC)	Chr 8: 145.12 – 145.13 Mb	Chr 15: 76.06 – 76.07 Mb
PubMed search	[1]	[2]

Poly [ADP-ribose] polymerase 10 is an enzyme that in humans is encoded by the PARP10 gene.^[1][2]

Poly(ADP-ribose) polymerases (PARPs), such as PARP10, regulate gene transcription by altering chromatin organization by adding ADP-ribose to histones. PARPs can also function as transcriptional cofactors (Yu et al., 2005).[supplied by OMIM]^[2]

References

1. ^ Ame JC, Spenlehauer C, de Murcia G (Jul 2004). "The PARP superfamily". Bioessays 26 (8): 882–93. doi:10.1002/bies.20085. PMID 15273990. 
2. ^ ^{a b} "Entrez Gene: PARP10 poly (ADP-ribose) polymerase family, member 10". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84875. 

Further reading

• Chou HY, Chou HT, Lee SC (2006). "CDK-dependent activation of poly(ADP-ribose) polymerase member 10 (PARP10).". J. Biol. Chem. 281 (22): 15201–7. doi:10.1074/jbc.M506745200. PMID 16455663. 
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1356129. 
• Yu M, Schreek S, Cerni C, et al. (2005). "PARP-10, a novel Myc-interacting protein with poly(ADP-ribose) polymerase activity, inhibits transformation.". Oncogene 24 (12): 1982–93. doi:10.1038/sj.onc.1208410. PMID 15674325. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.