ORAI2

ORAI2: ORAI calcium release-activated calcium modulator 2

Identifiers

Symbols ORAI2; C7orf19; CBCIP2; FLJ12474; FLJ14733; FLJ44818; MEM142B; TMEM142B

External IDs OMIM: 610929 MGI: 2443195 HomoloGene: 32799 GeneCards: ORAI2 Gene

Gene Ontology

Molecular function • protein binding

Cellular component • membrane
• integral to membrane

Sources: Amigo / QuickGO

Orthologs

Species Human Mouse

Entrez 80228 269717

Ensembl ENSG00000160991 ENSMUSG00000039747

UniProt Q96SN7 n/a

RefSeq (mRNA) NM_001126340.1 NM_178751.3

RefSeq (protein) NP_001119812.1 NP_848866.2

Location (UCSC) Chr 7:
102.07 – 102.1 Mb Chr 5:
136.62 – 136.65 Mb

PubMed search [1] [2]

Protein orai-2 is a protein that in humans is encoded by the ORAI2 gene.^[1]^[2]

References

^ Feske S, Gwack Y, Prakriya M, Srikanth S, Puppel SH, Tanasa B, Hogan PG, Lewis RS, Daly M, Rao A (May 2006). "A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function". Nature 441 (7090): 179–85. doi:10.1038/nature04702. PMID 16582901.

^ "Entrez Gene: TMEM142B transmembrane protein 142B". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=80228.

Further reading

DeHaven WI, Smyth JT, Boyles RR, Putney JW (2007). "Calcium inhibition and calcium potentiation of Orai1, Orai2, and Orai3 calcium release-activated calcium channels.". J. Biol. Chem. 282 (24): 17548–56. doi:10.1074/jbc.M611374200. PMID 17452328.

Mercer JC, Dehaven WI, Smyth JT et al. (2006). "LARGE STORE-OPERATED CALCIUM-SELECTIVE CURRENTS DUE TO CO-EXPRESSION OF ORAI1 OR ORAI2 WITH THE INTRACELLULAR CALCIUM SENSOR, STIM1". J. Biol. Chem. 281 (34): 24979–90. doi:10.1074/jbc.M604589200. PMC 1633822. PMID 16807233. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1633822.

Wan D, Gong Y, Qin W et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=524842.

Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.

Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.

Hillier LW, Fulton RS, Fulton LA et al. (2003). "The DNA sequence of human chromosome 7". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.

Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.

<Please add first missing authors to populate metadata.> (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.

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