DHDDS

Dehydrodolichyl diphosphate synthase
Identifiers
Symbols	DHDDS; CIT; CPT; DS; FLJ13102; HDS
External IDs	OMIM: 608172 MGI: 1914672 HomoloGene: 32615 GeneCards: DHDDS Gene
Gene Ontology Molecular function • protein binding • transferase activity, transferring alkyl or aryl (other than methyl) groups Biological process • metabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	79947	67422
Ensembl	ENSG00000117682	ENSMUSG00000012117
UniProt	Q86SQ9	Q99KU1
RefSeq (mRNA)	NM_024887.2	NM_026144.4
RefSeq (protein)	NP_079163.2	NP_080420.2
Location (UCSC)	Chr 1: 26.76 – 26.8 Mb	Chr 4: 133.52 – 133.56 Mb
PubMed search	[1]	[2]

Dehydrodolichyl diphosphate synthase is an enzyme that in humans is encoded by the DHDDS gene.^[1][2]

Dehydrodolichyl diphosphate (dedol-PP) synthase catalyzes cis-prenyl chain elongation to produce the polyprenyl backbone of dolichol, a glycosyl carrier lipid required for the biosynthesis of several classes of glycoproteins.[supplied by OMIM]^[2]

References

1. ^ Endo S, Zhang YW, Takahashi S, Koyama T (Feb 2003). "Identification of human dehydrodolichyl diphosphate synthase gene". Biochim Biophys Acta 1625 (3): 291–5. PMID 12591616. 
2. ^ ^{a b} "Entrez Gene: DHDDS dehydrodolichyl diphosphate synthase". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79947. 

Further reading

• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Jones J, Viswanathan K, Krag SS, Betenbaugh MJ (2005). "Polyprenyl lipid synthesis in mammalian cells expressing human cis-prenyl transferase.". Biochem. Biophys. Res. Commun. 331 (2): 379–83. doi:10.1016/j.bbrc.2005.03.181. PMID 15850770. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Kharel Y, Takahashi S, Yamashita S, Koyama T (2004). "In vivo interaction between the human dehydrodolichyl diphosphate synthase and the Niemann-Pick C2 protein revealed by a yeast two-hybrid system.". Biochem. Biophys. Res. Commun. 318 (1): 198–203. doi:10.1016/j.bbrc.2004.04.007. PMID 15110773. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Shridas P, Rush JS, Waechter CJ (2004). "Identification and characterization of a cDNA encoding a long-chain cis-isoprenyltranferase involved in dolichyl monophosphate biosynthesis in the ER of brain cells.". Biochem. Biophys. Res. Commun. 312 (4): 1349–56. doi:10.1016/j.bbrc.2003.11.065. PMID 14652022. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 

External links

• GeneReviews/NCBI/NIH/UW entry on Retinitis Pigmentosa Overview