MGST3

Microsomal glutathione S-transferase 3
Identifiers
Symbols	MGST3; GST-III
External IDs	OMIM: 604564 MGI: 1913697 HomoloGene: 3327 GeneCards: MGST3 Gene
EC number	2.5.1.18
Gene Ontology Molecular function • glutathione transferase activity • peroxidase activity • glutathione peroxidase activity • transferase activity Cellular component • membrane fraction • endoplasmic reticulum • endoplasmic reticulum membrane • microsome • membrane • integral to membrane Biological process • leukotriene production involved in inflammatory response • lipid metabolic process • xenobiotic metabolic process • signal transduction • leukotriene biosynthetic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4259	66447
Ensembl	ENSG00000143198	ENSMUSG00000026688
UniProt	O14880	Q9CPU4
RefSeq (mRNA)	NM_004528	NM_025569.1
RefSeq (protein)	NP_004519	NP_079845.1
Location (UCSC)	Chr 1: 165.6 – 165.63 Mb	Chr 1: 169.3 – 169.32 Mb
PubMed search	[1]	[2]

Microsomal glutathione S-transferase 3 is an enzyme that in humans is encoded by the MGST3 gene.^[1][2]

The MAPEG (Membrane-Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, several of which are involved the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes an enzyme that catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. This enzyme also demonstrates glutathione-dependent peroxidase activity towards lipid hydroperoxides.^[2]

References

1. ^ Jakobsson PJ, Mancini JA, Riendeau D, Ford-Hutchinson AW (Oct 1997). "Identification and characterization of a novel microsomal enzyme with glutathione-dependent transferase and peroxidase activities". J Biol Chem 272 (36): 22934–9. doi:10.1074/jbc.272.36.22934. PMID 9278457. 
2. ^ ^{a b} "Entrez Gene: MGST3 microsomal glutathione S-transferase 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4259. 

Further reading

• Jakobsson PJ, Morgenstern R, Mancini J, et al. (2000). "Membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG). A widespread protein superfamily.". Am. J. Respir. Crit. Care Med. 161 (2 Pt 2): S20–4. PMID 10673221. 
• Kobayashi K, Xin Y, Ymer SI, et al. (2007). "Subtractive hybridisation screen identifies genes regulated by glucose deprivation in human neuroblastoma cells.". Brain Res. 1170: 129–39. doi:10.1016/j.brainres.2007.07.042. PMID 17719568. 
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Thameem F, Yang X, Permana PA, et al. (2003). "Evaluation of the microsomal glutathione S-transferase 3 (MGST3) locus on 1q23 as a Type 2 diabetes susceptibility gene in Pima Indians.". Hum. Genet. 113 (4): 353–8. doi:10.1007/s00439-003-0980-y. PMID 12898215. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.