NCDN

Neurochondrin
Identifiers
Symbols	NCDN; KIAA0607
External IDs	OMIM: 608458 MGI: 1347351 HomoloGene: 8064 GeneCards: NCDN Gene
Gene Ontology Cellular component • nucleus • cytoplasm • cytosol • axon • dendrite • cell projection • neuronal cell body Biological process • neuron projection development • bone resorption • regulation of neuronal synaptic plasticity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23154	26562
Ensembl	ENSG00000020129	ENSMUSG00000028833
UniProt	Q9UBB6	Q9Z0E0
RefSeq (mRNA)	NM_001014839.1	NM_011986.4
RefSeq (protein)	NP_001014839.1	NP_036116.3
Location (UCSC)	Chr 1: 36.02 – 36.03 Mb	Chr 4: 126.42 – 126.43 Mb
PubMed search	[1]	[2]

Neurochondrin (also known as its murine homologue, Norbin) is a protein that in humans is encoded by the NCDN gene.^[1][2]

This gene encodes a leucine-rich cytoplasmic protein, which is highly similar to a mouse protein norbin that negatively regulates Ca/calmodulin-dependent protein kinase II phosphorylation and may be essential for spatial learning processes. Several alternatively spliced transcript variants of this gene have been described.^[2]

Norbin can modulate signaling activity and expression of metabotropic glutamate receptor 5; modulating mice with targeted deletion of NCDN in the brain have phenotypic traits usually found in the rodent models of schizophrenia, including disruptions in prepulse inhibition.^[3]

References

1. ^ Istvanffy R, Vogt Weisenhorn DM, Floss T, Wurst W (Apr 2004). "Expression of neurochondrin in the developing and adult mouse brain". Dev Genes Evol 214 (4): 206–9. doi:10.1007/s00427-004-0396-2. PMID 15007648. 
2. ^ ^{a b} "Entrez Gene: NCDN neurochondrin". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23154. 
3. ^ Wang H, Westin L, Nong Y, et al. (December 2009). "Norbin is an endogenous regulator of metabotropic glutamate receptor 5 signaling". Science 326 (5959): 1554–7. doi:10.1126/science.1178496. PMC 2796550. PMID 20007903. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2796550. 

Further reading

• Dateki M, Horii T, Kasuya Y, et al. (2005). "Neurochondrin negatively regulates CaMKII phosphorylation, and nervous system-specific gene disruption results in epileptic seizure.". J. Biol. Chem. 280 (21): 20503–8. doi:10.1074/jbc.M414033200. PMID 15790563. 
• Mochizuki R, Dateki M, Yanai K, et al. (2003). "Targeted disruption of the neurochondrin/norbin gene results in embryonic lethality.". Biochem. Biophys. Res. Commun. 310 (4): 1219–26. doi:10.1016/j.bbrc.2003.09.153. PMID 14559245. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Tchernev VT, Mansfield TA, Giot L, et al. (2002). "The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins.". Mol. Med. 8 (1): 56–64. PMC 2039936. PMID 11984006. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2039936. 
• Ohoka Y, Hirotani M, Sugimoto H, et al. (2001). "Semaphorin 4C, a transmembrane semaphorin, [corrected] associates with a neurite-outgrowth-related protein, SFAP75.". Biochem. Biophys. Res. Commun. 280 (1): 237–43. doi:10.1006/bbrc.2000.4080. PMID 11162505. 
• Mochizuki R, Ishizuka Y, Yanai K, et al. (2000). "Corrigendum to 'Molecular cloning and expression of human neurochondrin-1 and -2'(1).". Biochim. Biophys. Acta 1490 (3): 367–8. PMID 10684983. 
• Mochizuki R, Ishizuka Y, Yanai K, et al. (1999). "Molecular cloning and expression of human neurochondrin-1 and -2.". Biochim. Biophys. Acta 1446 (3): 397–402. PMID 10524216. 
• Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.