DGKB

Diacylglycerol kinase, beta 90kDa
Identifiers
Symbols	DGKB; DAGK2; DGK; DGK-BETA; KIAA0718
External IDs	OMIM: 604070 MGI: 2442474 HomoloGene: 37875 GeneCards: DGKB Gene
EC number	2.7.1.107
Gene Ontology Molecular function • nucleotide binding • diacylglycerol kinase activity • calcium ion binding • protein binding • ATP binding • transferase activity Cellular component • membrane fraction • cytoplasm • plasma membrane Biological process • activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway • blood coagulation • platelet activation • intracellular signal transduction Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1607	217480
Ensembl	ENSG00000136267	ENSMUSG00000036095
UniProt	Q9Y6T7	Q3TSN3
RefSeq (mRNA)	NM_004080.2	NM_178681.4
RefSeq (protein)	NP_004071.1	NP_848796.2
Location (UCSC)	Chr 7: 14.18 – 15.01 Mb	Chr 12: 38.61 – 39.36 Mb
PubMed search	[1]	[2]

Diacylglycerol kinase beta is an enzyme that in humans is encoded by the DGKB gene.^[1][2]

Diacylglycerol kinases (DGKs) are regulators of the intracellular concentration of the second messenger diacylglycerol (DAG) and thus play a key role in cellular processes. Nine mammalian isotypes have been identified, which are encoded by separate genes. Mammalian DGK isozymes contain a conserved catalytic (kinase) domain and a cysteine-rich domain (CRD). The protein encoded by this gene is a diacylglycerol kinase, beta isotype. Two alternatively spliced transcript variants have been found for this gene.^[2]

References

1. ^ Goto K, Kondo H (Sep 1993). "Molecular cloning and expression of a 90-kDa diacylglycerol kinase that predominantly localizes in neurons". Proc Natl Acad Sci U S A 90 (16): 7598–602. doi:10.1073/pnas.90.16.7598. PMC 47189. PMID 7689223. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=47189. 
2. ^ ^{a b} "Entrez Gene: DGKB diacylglycerol kinase, beta 90kDa". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1607. 

Further reading

• Ewing RM, Chu P, Elisma F et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948. 
• Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Hillier LW, Fulton RS, Fulton LA et al. (2003). "The DNA sequence of human chromosome 7". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948. 
• Scherer SW, Cheung J, MacDonald JR et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2882961. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Caricasole A, Bettini E, Sala C et al. (2002). "Molecular cloning and characterization of the human diacylglycerol kinase beta (DGKbeta) gene: alternative splicing generates DGKbeta isotypes with different properties". J. Biol. Chem. 277 (7): 4790–6. doi:10.1074/jbc.M110249200. PMID 11719522. 
• Nagase T, Ishikawa K, Suyama M et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.