PDCD7

Programmed cell death 7
Identifiers
Symbols	PDCD7; ES18; FLJ54213; HES18; MGC22015
External IDs	OMIM: 608138 MGI: 1859170 HomoloGene: 4170 GeneCards: PDCD7 Gene
Gene Ontology Cellular component • nucleus • U12-type spliceosomal complex Biological process • apoptosis • induction of apoptosis • RNA splicing • response to glucocorticoid stimulus Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10081	50996
Ensembl	ENSG00000090470	ENSMUSG00000041837
UniProt	Q8N8D1	Q3U2X6
RefSeq (mRNA)	NM_005707	NM_016688.2
RefSeq (protein)	NP_005698	NP_057897.2
Location (UCSC)	Chr 15: 65.41 – 65.43 Mb	Chr 9: 65.19 – 65.21 Mb
PubMed search	[1]	[2]

Programmed cell death protein 7 is a protein that in humans is encoded by the PDCD7 gene.^[1][2]

This gene encodes a protein with sequence similarity to a mouse protein originally identified in embryonic stem cells. In mouse T-cell lines, this protein appears to be related to glucocorticoid- and staurine-induced apoptotic pathways, and to be linked to ceramide-mediated signalling. These observations suggest that this gene product is involved in specific apoptotic processes in T-cells.^[2]

References

1. ^ Park EJ, Kim JH, Seong RH, Kim CG, Park SD, Hong SH (Apr 1999). "Characterization of a novel mouse cDNA, ES18, involved in apoptotic cell death of T-cells". Nucleic Acids Res 27 (6): 1524–30. doi:10.1093/nar/27.6.1524. PMC 148348. PMID 10037816. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=148348. 
2. ^ ^{a b} "Entrez Gene: PDCD7 programmed cell death 7". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10081. 

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=442148. 
• Will CL, Schneider C, Hossbach M, et al. (2004). "The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome". RNA 10 (6): 929–41. doi:10.1261/rna.7320604. PMC 1370585. PMID 15146077. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1370585. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.