TMSB4X

Thymosin, beta 4, X-linked, also known as TMSB4X, is a human gene.cite web | title = Entrez Gene: TMSB4X thymosin, beta 4, X-linked| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7114| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes an actin sequestering protein which plays a role in regulation of actin polymerization. The protein is also involved in cell proliferation, migration, and differentiation. This gene escapes X inactivation and has a homolog on chromosome Y.cite web | title = Entrez Gene: TMSB4X thymosin, beta 4, X-linked| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7114| accessdate = ]

ee also

* Thymosin

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Huff T, Müller CS, Otto AM, "et al." |title=beta-Thymosins, small acidic peptides with multiple functions. |journal=Int. J. Biochem. Cell Biol. |volume=33 |issue= 3 |pages= 205–20 |year= 2001 |pmid= 11311852 |doi=
*cite journal | author=Bubb MR |title=Thymosin beta 4 interactions. |journal=Vitam. Horm. |volume=66 |issue= |pages= 297–316 |year= 2003 |pmid= 12852258 |doi=
*cite journal | author=Goldschmidt-Clermont PJ, Furman MI, Wachsstock D, "et al." |title=The control of actin nucleotide exchange by thymosin beta 4 and profilin. A potential regulatory mechanism for actin polymerization in cells. |journal=Mol. Biol. Cell |volume=3 |issue= 9 |pages= 1015–24 |year= 1992 |pmid= 1330091 |doi=
*cite journal | author=Sanders MC, Goldstein AL, Wang YL |title=Thymosin beta 4 (Fx peptide) is a potent regulator of actin polymerization in living cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 10 |pages= 4678–82 |year= 1992 |pmid= 1584803 |doi=
*cite journal | author=Safer D, Elzinga M, Nachmias VT |title=Thymosin beta 4 and Fx, an actin-sequestering peptide, are indistinguishable. |journal=J. Biol. Chem. |volume=266 |issue= 7 |pages= 4029–32 |year= 1991 |pmid= 1999398 |doi=
*cite journal | author=Clauss IM, Wathelet MG, Szpirer J, "et al." |title=Human thymosin-beta 4/6-26 gene is part of a multigene family composed of seven members located on seven different chromosomes. |journal=Genomics |volume=9 |issue= 1 |pages= 174–80 |year= 1991 |pmid= 2004759 |doi=
*cite journal | author=Gómez-Márquez J, Dosil M, Segade F, "et al." |title=Thymosin-beta 4 gene. Preliminary characterization and expression in tissues, thymic cells, and lymphocytes. |journal=J. Immunol. |volume=143 |issue= 8 |pages= 2740–4 |year= 1989 |pmid= 2677145 |doi=
*cite journal | author=Soma G, Murata M, Kitahara N, "et al." |title=Detection of a countertranscript in promyelocytic leukemia cells HL60 during early differentiation by TPA. |journal=Biochem. Biophys. Res. Commun. |volume=132 |issue= 1 |pages= 100–9 |year= 1985 |pmid= 2998351 |doi=
*cite journal | author=Gondo H, Kudo J, White JW, "et al." |title=Differential expression of the human thymosin-beta 4 gene in lymphocytes, macrophages, and granulocytes. |journal=J. Immunol. |volume=139 |issue= 11 |pages= 3840–8 |year= 1988 |pmid= 3500230 |doi=
*cite journal | author=Friedman RL, Manly SP, McMahon M, "et al." |title=Transcriptional and posttranscriptional regulation of interferon-induced gene expression in human cells. |journal=Cell |volume=38 |issue= 3 |pages= 745–55 |year= 1984 |pmid= 6548414 |doi=
*cite journal | author=Erickson-Viitanen S, Ruggieri S, Natalini P, Horecker BL |title=Distribution of thymosin beta 4 in vertebrate classes. |journal=Arch. Biochem. Biophys. |volume=221 |issue= 2 |pages= 570–6 |year= 1983 |pmid= 6838210 |doi=
*cite journal | author=Pantaloni D, Carlier MF |title=How profilin promotes actin filament assembly in the presence of thymosin beta 4. |journal=Cell |volume=75 |issue= 5 |pages= 1007–14 |year= 1994 |pmid= 8252614 |doi=
*cite journal | author=Van Troys M, Dewitte D, Goethals M, "et al." |title=The actin binding site of thymosin beta 4 mapped by mutational analysis. |journal=EMBO J. |volume=15 |issue= 2 |pages= 201–10 |year= 1996 |pmid= 8617195 |doi=
*cite journal | author=Feinberg J, Heitz F, Benyamin Y, Roustan C |title=The N-terminal sequences (5-20) of thymosin beta 4 binds to monomeric actin in an alpha-helical conformation. |journal=Biochem. Biophys. Res. Commun. |volume=222 |issue= 1 |pages= 127–32 |year= 1996 |pmid= 8630056 |doi=
*cite journal | author=Safer D, Sosnick TR, Elzinga M |title=Thymosin beta 4 binds actin in an extended conformation and contacts both the barbed and pointed ends. |journal=Biochemistry |volume=36 |issue= 19 |pages= 5806–16 |year= 1997 |pmid= 9153421 |doi= 10.1021/bi970185v
*cite journal | author=Malinda KM, Goldstein AL, Kleinman HK |title=Thymosin beta 4 stimulates directional migration of human umbilical vein endothelial cells. |journal=FASEB J. |volume=11 |issue= 6 |pages= 474–81 |year= 1997 |pmid= 9194528 |doi=
*cite journal | author=Lahn BT, Page DC |title=Functional coherence of the human Y chromosome. |journal=Science |volume=278 |issue= 5338 |pages= 675–80 |year= 1997 |pmid= 9381176 |doi=
*cite journal | author=Chen J, Peterson RT, Schreiber SL |title=Alpha 4 associates with protein phosphatases 2A, 4, and 6. |journal=Biochem. Biophys. Res. Commun. |volume=247 |issue= 3 |pages= 827–32 |year= 1998 |pmid= 9647778 |doi= 10.1006/bbrc.1998.8792
*cite journal | author=Huff T, Ballweber E, Humeny A, "et al." |title=Thymosin beta(4) serves as a glutaminyl substrate of transglutaminase. Labeling with fluorescent dansylcadaverine does not abolish interaction with G-actin. |journal=FEBS Lett. |volume=464 |issue= 1-2 |pages= 14–20 |year= 2000 |pmid= 10611475 |doi=
*cite journal | author=De La Cruz EM, Ostap EM, Brundage RA, "et al." |title=Thymosin-beta(4) changes the conformation and dynamics of actin monomers. |journal=Biophys. J. |volume=78 |issue= 5 |pages= 2516–27 |year= 2000 |pmid= 10777749 |doi=

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