RAB27A

RAB27A, member RAS oncogene family, also known as RAB27A, is a human gene.cite web | title = Entrez Gene: RAB27A RAB27A, member RAS oncogene family| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5873| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction. Mutations in this gene are associated with Griscelli syndrome type 2. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.cite web | title = Entrez Gene: RAB27A RAB27A, member RAS oncogene family| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5873| accessdate = ]

ee also

* Rab27

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Nagata K, Itoh H, Katada T, "et al." |title=Purification, identification, and characterization of two GTP-binding proteins with molecular weights of 25,000 and 21,000 in human platelet cytosol. One is the rap1/smg21/Krev-1 protein and the other is a novel GTP-binding protein. |journal=J. Biol. Chem. |volume=264 |issue= 29 |pages= 17000–5 |year= 1989 |pmid= 2507536 |doi=
*cite journal | author=Seabra MC, Ho YK, Anant JS |title=Deficient geranylgeranylation of Ram/Rab27 in choroideremia. |journal=J. Biol. Chem. |volume=270 |issue= 41 |pages= 24420–7 |year= 1995 |pmid= 7592656 |doi=
*cite journal | author=Chen D, Guo J, Miki T, "et al." |title=Molecular cloning and characterization of rab27a and rab27b, novel human rab proteins shared by melanocytes and platelets. |journal=Biochem. Mol. Med. |volume=60 |issue= 1 |pages= 27–37 |year= 1997 |pmid= 9066979 |doi=
*cite journal | author=Tolmachova T, Ramalho JS, Anant JS, "et al." |title=Cloning, mapping and characterization of the human RAB27A gene. |journal=Gene |volume=239 |issue= 1 |pages= 109–16 |year= 1999 |pmid= 10571040 |doi=
*cite journal | author=Ménasché G, Pastural E, Feldmann J, "et al." |title=Mutations in RAB27A cause Griscelli syndrome associated with haemophagocytic syndrome. |journal=Nat. Genet. |volume=25 |issue= 2 |pages= 173–6 |year= 2000 |pmid= 10835631 |doi= 10.1038/76024
*cite journal | author=Hu RM, Han ZG, Song HD, "et al." |title=Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 17 |pages= 9543–8 |year= 2000 |pmid= 10931946 |doi= 10.1073/pnas.160270997
*cite journal | author=Haddad EK, Wu X, Hammer JA, Henkart PA |title=Defective granule exocytosis in Rab27a-deficient lymphocytes from Ashen mice. |journal=J. Cell Biol. |volume=152 |issue= 4 |pages= 835–42 |year= 2001 |pmid= 11266473 |doi=
*cite journal | author=Bahadoran P, Aberdam E, Mantoux F, "et al." |title=Rab27a: A key to melanosome transport in human melanocytes. |journal=J. Cell Biol. |volume=152 |issue= 4 |pages= 843–50 |year= 2001 |pmid= 11266474 |doi=
*cite journal | author=Xu XR, Huang J, Xu ZG, "et al." |title=Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 26 |pages= 15089–94 |year= 2002 |pmid= 11752456 |doi= 10.1073/pnas.241522398
*cite journal | author=Kuroda TS, Fukuda M, Ariga H, Mikoshiba K |title=The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain. |journal=J. Biol. Chem. |volume=277 |issue= 11 |pages= 9212–8 |year= 2002 |pmid= 11773082 |doi= 10.1074/jbc.M112414200
*cite journal | author=Fukuda M, Kuroda TS, Mikoshiba K |title=Slac2-a/melanophilin, the missing link between Rab27 and myosin Va: implications of a tripartite protein complex for melanosome transport. |journal=J. Biol. Chem. |volume=277 |issue= 14 |pages= 12432–6 |year= 2002 |pmid= 11856727 |doi= 10.1074/jbc.C200005200
*cite journal | author=Yi Z, Yokota H, Torii S, "et al." |title=The Rab27a/granuphilin complex regulates the exocytosis of insulin-containing dense-core granules. |journal=Mol. Cell. Biol. |volume=22 |issue= 6 |pages= 1858–67 |year= 2002 |pmid= 11865063 |doi=
*cite journal | author=Strom M, Hume AN, Tarafder AK, "et al." |title=A family of Rab27-binding proteins. Melanophilin links Rab27a and myosin Va function in melanosome transport. |journal=J. Biol. Chem. |volume=277 |issue= 28 |pages= 25423–30 |year= 2002 |pmid= 11980908 |doi= 10.1074/jbc.M202574200
*cite journal | author=Wu X, Wang F, Rao K, "et al." |title=Rab27a is an essential component of melanosome receptor for myosin Va. |journal=Mol. Biol. Cell |volume=13 |issue= 5 |pages= 1735–49 |year= 2002 |pmid= 12006666 |doi= 10.1091/mbc.01-12-0595
*cite journal | author=Kuroda TS, Fukuda M, Ariga H, Mikoshiba K |title=Synaptotagmin-like protein 5: a novel Rab27A effector with C-terminal tandem C2 domains. |journal=Biochem. Biophys. Res. Commun. |volume=293 |issue= 3 |pages= 899–906 |year= 2002 |pmid= 12051743 |doi= 10.1016/S0006-291X(02)00320-0
*cite journal | author=Anikster Y, Huizing M, Anderson PD, "et al." |title=Evidence that Griscelli syndrome with neurological involvement is caused by mutations in RAB27A, not MYO5A. |journal=Am. J. Hum. Genet. |volume=71 |issue= 2 |pages= 407–14 |year= 2002 |pmid= 12058346 |doi=
*cite journal | author=Nagashima K, Torii S, Yi Z, "et al." |title=Melanophilin directly links Rab27a and myosin Va through its distinct coiled-coil regions. |journal=FEBS Lett. |volume=517 |issue= 1-3 |pages= 233–8 |year= 2002 |pmid= 12062444 |doi=
*cite journal | author=Torii S, Zhao S, Yi Z, "et al." |title=Granuphilin modulates the exocytosis of secretory granules through interaction with syntaxin 1a. |journal=Mol. Cell. Biol. |volume=22 |issue= 15 |pages= 5518–26 |year= 2002 |pmid= 12101244 |doi=
*cite journal | author=Wistow G, Bernstein SL, Wyatt MK, "et al." |title=Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants. |journal=Mol. Vis. |volume=8 |issue= |pages= 205–20 |year= 2002 |pmid= 12107410 |doi=
*cite journal | author=Barral DC, Ramalho JS, Anders R, "et al." |title=Functional redundancy of Rab27 proteins and the pathogenesis of Griscelli syndrome. |journal=J. Clin. Invest. |volume=110 |issue= 2 |pages= 247–57 |year= 2002 |pmid= 12122117 |doi=

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